Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Neutrophils to Lymphocytes and Platelets ratio (N/LP).
- Who it may be relevant to
- Registry conditions: Neutrophils to Lymphocytes, Platelets, Procalcitonin, Total Leucocytic Count. Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparison Between Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.
Overview
This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.
Detailed description
Sepsis affects more than 30 million people annually worldwide and is one of the significant causes of death in critical patients worldwide. Any infected person can potentially develop sepsis, and the incidence of sepsis is as high as 1-2% of all hospitalized patients.
Many potential sepsis biomarkers have been proposed, procalcitonin (PCT) and C-reactive protein (CRP) being the most frequently studied.
The ratio of neutrophils to lymphocytes and platelets (N/LP) is a low-cost measure that can be obtained through routine blood tests and is often used to reflect the body's inflammatory state.
Interventions
- Diagnostic test Neutrophils to Lymphocytes and Platelets ratio (N/LP)
The Neutrophils to Lymphocytes and Platelets ratio (N/LP) will be measured
Primary outcome measures
- Levels of Neutrophils to Lymphocytes and Platelets ratio [Time frame: 28 days post-procedure]
Secondary outcome measures (2)
- Procalcitonin (PCT) [Time frame: 28 days post-procedure]
- Total Leukocytic Count (TLC) [Time frame: 28 days post-procedure]
Eligibility criteria
Inclusion criteria
- Age from 18 to 70 years old.
- Both sexes.
- Septic patients (under the third international consensus definitions of sepsis and septic shock).
Exclusion criteria
- Pregnancy
- Malignancy
- On immunosuppressive therapy
- Hematological Disorders
- Major Trauma
- Major Burns
- Child-Pugh Class C Liver Cirrhosis
- On Hemodialysis
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Ain Shams University — Cairo
Identifiers
NCT: NCT07200817 · FMASU MD224/2024