Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Achieva 3.0T dStream Philips.
- Who it may be relevant to
- Registry conditions: Stroke, Ischemic. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination, a Pilot Study and Proof of Concept
Overview
Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy). The recent concept of MRI "Fingerprint" (Magnetic Resonance Fingerprinting, MRF) allows the production of a rapid single sequence and the extraction of numerous parameters. Demonstrating the feasibility and interpretability of multimodal MRI images acquired in MRF would make it possible to consider implementing and, ultimately, replacing conventional sequences, with the aim of shortening acute stroke management times, increasing the number of sequences acquired within a short timeframe (by increasing informativeness), and thus improving patients\' short and long-term vital and functional prognosis.
Interventions
- Device Achieva 3.0T dStream Philips
Classic and MRF sequences will be carried out on the clinical machine (Achieva 3.0T dStream Philips) of the IRMaGe platform (CHUGA, Université Grenoble Alpes, Inserm, CNRS).
Primary outcome measures
- Success rate and interpretability of images acquired in MRF [Time frame: From enrollment to the end of the MRI exam]
Secondary outcome measures (1)
- Characterize and extract the physical parameters of the signal acquired with MRF. [Time frame: From enrollment to the end of the MRI exam]
Eligibility criteria
Inclusion criteria
- Age > 18 years
- Subacute ischemic stroke patients (< 15 days after onset)
- Middle cerebral artery or anterior cerebral artery territory stroke
- Modified Rankin Scale (mRS) = 0-4
Exclusion criteria
\* MRI contraindications
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Sequential
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
France · 1 center
- Chu Grenoble Alpes — Grenoble
Identifiers
NCT: NCT07199920 · 38RC23.0410