Association Between Plasma D Dimer in Adult CAP and Severity of Inflammatory Response and Survival
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Blood Product.
- Who it may be relevant to
- Registry conditions: D-dimer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Association Between Elevated Plasma D-dimer in Adult Community-acquired Pneumonia Patients and Severity of Inflammatory Response and Survival
Overview
This observational study aims to investigate the association between elevated plasma D-dimer levels and the inflammatory response, as well as its impact on survival in adult patients with community-acquired pneumonia. the study participants will be subjected to sampling for D-dimer and calculation of CURB-65 score. this aims to find the relation between them
Detailed description
Community-acquired pneumonia (CAP) is a common and potentially life-threatening infection that affects millions of individuals worldwide each year.
D-dimer is a fibrin degradation product that is elevated in many conditions associated with inflammation and coagulation activation, including pneumonia.
This is an observational study including a minimum of 50 patients with CAP
Patients who will be admitted to the Chest department, or coming to the outpatient clinic at Ain-Shams University Hospitals with CAP, and have the following inclusions:
1. age ≥18 years 2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence. 3. Did not have any clinical or radiological signs suggesting COVID-19 pneumonia Exclusion criteria Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
All patients will be subjected to the following: -
1. Full medical history, demographics 2. Thorough clinical examination. 3. laboratory values (including white blood cell count, CRP, and D-dimer), With pre and post sample known precautions (8). 4. Radiological findings (CXR). 5. Severity of illness (based on the CURB-65 score).
Interventions
- Other Blood Product
blood sample for D-dimer
Primary outcome measures
- find the correlation between plasma D-dimer level and the severity of CAP [Time frame: in 6 months]
Eligibility criteria
Inclusion criteria
- Patients who will be admitted to the Chest department, or coming to the outpatient clinic at Ain-Shams University Hospitals with CAP, and have the following inclusions:
- age ≥18 years
- diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.
Exclusion criteria
- Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
- patients who have any clinical or radiological signs suggesting COVID-19 pneumonia.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
Egypt · 1 center
- Ain Shams University hospitals — Cairo
Identifiers
NCT: NCT07199530 · FAMSU R 135/2025