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Recruiting NCT07196514

Effects of 8 Weeks of Turmeric Ingestion on Physiology and Wellbeing in Healthy Older Adults

No phase Interventional Turmeric Placebo

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Raw turmeric shots, Placebo.
Who it may be relevant to
Registry conditions: Turmeric, Placebo. Basic parameters: 40 years — 95 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United Kingdom
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Exploring the Effects of an 8-week Turmeric Supplementation on Aspects of Physiology and Wellbeing in Healthy Older Adults

Overview

Curcumin (a bioactive compound found in turmeric) has demonstrated anti-inflammatory and antioxidant properties, and there is evidence to suggest that it may produce improvements in quality of life and markers of health in humans with various conditions. To date, the research has often focussed on the effects of curcumin in human participants with a particular condition. However, turmeric contains hundreds of other bioactive compounds (including other curcuminoids and essential oils) and may be able to benefit a wide range of older adults. Therefore, the aim of this study is to investigate the effects of twice daily consumption of a turmeric beverage for 8-weeks on the physiology and wellbeing of older adults (versus placebo).

Interventions

  • Dietary supplement Raw turmeric shots
    This group will take one 60 mL commercially-available shot (containing 30% turmeric) twice per day for 8 weeks.
  • Other Placebo
    This group will take one placebo shot (containing a small amount of turmeric for taste-matching purposes) twice per day for 8 weeks.

Primary outcome measures

  • Plasma/serum Brain-derived neurotrophic factor [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Plasma/serum total cholesterol [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Chalder Fatigue Scale (CFS) [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
Secondary outcome measures (12)
  • Plasma/serum creatinine [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Depression Anxiety Stress Scales - 21 items (DASS-21) [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • McGill Pain Questionnaire [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • 36-Item Short Form Survey (SF-36) [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Plasma/serum ALT [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Plasma/serum AST [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Plasma/serum LDL cholesterol [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Plasma/serum HDL cholesterol [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Plasma/serum ALP [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Serum GGT [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Plasma/serum LDH [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]
  • Plasma/serum creatine kinase [Time frame: Two timepoints: 1) baseline 2) after 8 week intervention]

Eligibility criteria

Inclusion criteria

\- Body Mass Index between 18.5-39.9.

Exclusion criteria

  • History of, or currently diagnosed with, a cardiovascular disease.
  • Diagnosed with diabetes.
  • Diagnosed with a liver, lung, or kidney disease.
  • Diagnosed with osteoporosis.
  • Diagnosed with dementia.
  • Diagnosed with cancer.
  • Use of medications/supplements/herbal remedies with human evidence of a significant interaction with turmeric.
  • Allergy to turmeric, lemon, black pepper, watermelon, water, pineapple, magnesium or vitamin C.
  • Pregnant, attempting to become pregnant, or breastfeeding.
  • Regular (once per week or more) use of turmeric shots / supplements within the last 3 months.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Double blind
Primary purpose
Basic science

Study locations

United Kingdom · 1 center
  • Nottingham Trent University, Clifton campus — Nottingham

Identifiers

NCT: NCT07196514 · 2268061

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗