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Not yet recruiting NCT07196215

Comparison of Post-operative Pain After Different Root Canal Irrigant Activation Methods

No phase Interventional Irriversible Pulpitis Irrigation Activation, Patient

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: passive ultrasonic activation, sonic activation.
Who it may be relevant to
Registry conditions: Irriversible Pulpitis, Irrigation, Activation, Patient. Basic parameters: 20 years — 50 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Comparison of Post-operative Pain After Different Root Canal Irrigant Activation Methods in Maxillary Incisors With Symptomatic Irreversible Pulpitis

Overview

root canal irrigation protocol

Detailed description

To compare mean post-operative pain intensity at different time intervals (24h and 48h) using visual analogue scale (VAS) in maxillary incisors with symptomatic irreversible pulpitis using two different irrigation activation methods (passive ultrasonic activation and sonic activation using EndoActivator).

Interventions

  • Procedure passive ultrasonic activation
    passive ultrasonic irrigant activation will be performed by using a stainless steel ultrasonic Irrisafe file of size 20 (IRRI S 21/25; VDW, Germany) mounted on ultrasonic unit (Woodpecker Ultrasonic Scaler UDS-J). The file will be kept 2 mm short of working length loosely without binding to the canal. 2.5% NaOCl will be activated for 30 seconds by using a power setting of five
  • Procedure sonic activation
    root canals will be filled with 2.5% sodium hypochlorite and medium size tip (red, 25/04) of EndoAcivator (YAHOPE A3, China) will be used keeping it 2 mm short of working length. The activation of irrigant will be done in 2-3 mm vertical strokes for 30 seconds in between each instrumentation

Primary outcome measures

  • pain score on visual analogue scale [Time frame: 48 hours]

Eligibility criteria

Inclusion criteria

  • • Patients in good health with no systemic disease (ASA Class I or II)
  • Age range is between 20 to 50 years.
  • Patients diagnosed with symptomatic irreversible pulpitis in maxillary incisor teeth.
  • Patients who can understand VAS.
  • Patients who give verbal consent to participate voluntarily in the study.

Exclusion criteria

  • • History of systemic disorder.
  • Pregnant / lactating females (As per medical record/verbally)
  • Patients who had taken preoperative drugs as anti-inflammatory analgesic or antibiotics.
  • Patients with swelling or acute peri-apical abscess.
  • Tooth not suitable for restoration.
  • Periodontally compromised teeth.
  • Retreatment cases.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Publications

  • Gundogar M, Sezgin GP, Kaplan SS, Ozyurek H, Uslu G, Ozyurek T. Postoperative pain after different irrigation activation techniques: a randomized, clinical trial. Odontology. 2021 Apr;109(2):385-392. doi: 10.1007/s10266-020-00553-5. Epub 2020 Sep 11. PMID 32915346
  • Narla RK, J RK, Pavuluri TC, P KC, Penumaka R, Nagelli RK. Effect of Different Irrigant Activation Techniques on the Penetration of Calcium Hydroxide, an Intracanal Medicament: An In Vitro Study. Cureus. 2023 Nov 13;15(11):e48768. doi: 10.7759/cureus.48768. eCollection 2023 Nov. PMID 38098913
  • 7. Nivedhitha S. Influence of different irrigant activation techniques in post-operative endodontic pain-a review of literature. Int J Dentistry Oral Sci. 2021;8(5):2659-65.
  • 6. Abou Khalaf Y, Hashem A, Kamel W, Badr M. Postoperative pain after different root canal irrigant activation methods; (randomized clinical trial). Future Dent J. 2021;7(1):1-6.
  • 5. Elzainy P, Hussein W, Hashem A, Badr M. Post-operative pain after different root canal irrigant activation methods in patients with acute apical periodontitis (Randomized Clinical Trial). Open Access Maced J Med Sci. 2022;10(D):331-7.
  • Kumar P, Yadav SK, Chugh VK, Sharma R, Pathak K, Duraisamy A. Comparative Assessment of Postoperative Pain After Three Irrigation Techniques in Single-Rooted Teeth With Symptomatic Irreversible Pulpitis and Symptomatic Apical Periodontitis: A Randomized Controlled Trial. Cureus. 2024 Jul 29;16(7):e65618. doi: 10.7759/cureus.65618. eCollection 2024 Jul. PMID 39205753
  • 3. Salim A, Darrag A, Ghoneim W. Post-operative pain after single-visit endodontic treatment using different root canal irrigation activating techniques. Egypt Dent J. 2021;67(4):3719-30.
  • Sathorn C, Parashos P, Messer H. The prevalence of postoperative pain and flare-up in single- and multiple-visit endodontic treatment: a systematic review. Int Endod J. 2008 Feb;41(2):91-9. doi: 10.1111/j.1365-2591.2007.01316.x. Epub 2007 Oct 23. PMID 17956561

Identifiers

NCT: NCT07196215 · TUF/IRB/21/25

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗