Stress Hyperglycemia Ratio and Postoperative Delirium
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: no intervention.
- Who it may be relevant to
- Registry conditions: Postoperative Delirium. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Preoperative Stress Hyperglycemia Ratio and Postoperative Delirium
Overview
Postoperative delirium is a common and serious complication associated with prolonged hospitalization, increased morbidity and mortality, and elevated healthcare costs. Identifying reliable predictive biomarkers for early risk stratification is crucial for implementing preventive strategies and improving patient outcomes. The stress hyperglycemia ratio (SHR) is an emerging biomarker that quantifies stress-induced hyperglycemia relative to baseline glycemic status, providing an assessment of physiological stress. This metric has been associated with various adverse outcomes. Given that surgical stress triggers neuroendocrine and inflammatory responses potentially contributing to delirium pathogenesis, SHR may indicate vulnerability to postoperative cognitive dysfunction. The primary objective of this retrospective study is to investigate the association between preoperative stress hyperglycemia ratio and postoperative delirium development. Additionally, we aim to evaluate the predictive value of preoperative SHR for postoperative delirium risk stratification. This investigation may provide insights into metabolic stress-related mechanisms underlying postoperative cognitive outcomes and identify a clinically applicable biomarker for delirium risk assessment.
Interventions
- Other no intervention
no intervention
Primary outcome measures
- Number of participants with postoperative delirium [Time frame: Perioperative/Periprocedural]
Eligibility criteria
Inclusion criteria
- Adults aged ≥18 years
- Underwent non-neurosurgical and non-cardiac surgical procedures
- For patients with multiple qualifying surgical procedures during the study period, only data from the first eligible surgery were analyzed
Exclusion criteria
- American Society of Anesthesiologists (ASA) physical status V
- Procedural sedation or anesthesia performed outside the operating room, or total anesthesia duration ≤60 minutes
- Preoperative delirium or dementia
- Insufficient laboratory data for calculating the stress hyperglycemia ratio (SHR)
- Missing values for essential confounding variables required for multivariable analysis
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07194096 · TJ-IRB202509010A