Evaluation of CT-XPI
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: CT scan.
- Who it may be relevant to
- Registry conditions: CT Scan, Computed Tomography. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Evaluation of Computed Tomography X-ray-Pulsatility Index (CT-XPI)
Overview
The goal of this clinical trial is to learn if a new computed tomography (CT) lung perfusion imaging method is as effective as standard of care (SOC) CT imaging. The main question it aims to answer is: * Does the new contrast-free method provide more information about lung perfusion than SOC? Participants will undergo a 30 minute chest CT.
Detailed description
The purpose of the study is to evaluate X-ray Pulsatility Index using prospectively acquired dynamic CT, which is different from conventional static CT scans.
The primary objective of this study is to collect dynamic CT scan data with human participants using high frame rate imaging methods to produce a map of lung perfusion.
Interventions
- Diagnostic test CT scan
Dynamic contrast-free chest CT scan
Primary outcome measures
- Lung x-ray pulsatility index (XPI) [Time frame: 30 minutes]
- Magnitude of XPI [Time frame: 30 minutes]
- Presence of XPI [Time frame: 30 minutes]
- Spatial distribution of XPI signal [Time frame: 30 minutes]
Eligibility criteria
Inclusion criteria
- Age 18 years or older
- Able to sign and date the informed consent form
- Will undergo a clinically-indicated CT exam of the head, neck, chest, abdomen, pelvis, or extremities
Exclusion criteria
- Pregnant or lactating
- In need of urgent or emergent care
- Have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the participant
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
United States · 1 center
- University of Wisconsin - Madison — Madison
Identifiers
NCT: NCT07192133 · 2025-0586 · SMPH/RADIOLOGY/RADIOLOGY · AS · Protocol Version 1/18/2025