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Recruiting NCT07191275

Study on the Effect of Transcranial Magnetic Stimulation on the Perception of Emotional Images

No phase Interventional Emotional Memory

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation, Control continuous 30 Hz thetaburst transcranial magnetic stimulation.
Who it may be relevant to
Registry conditions: Emotional Memory. Basic parameters: 18 years — 30 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Switzerland
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

The Effect of TMS on Emotional Valence Evaluation of Aversive Pictures

Overview

The goal of the current clinical trial is to investigate whether transcranial magnetic stimulation (TMS) over specific brain areas can influence the perception of emotional images and emotional memory. TMS is a non-invasive superficial brain stimulation generated by a magnetic field. The results of the study aim to provide valuable insights for the use of TMS in the investigation of mental processes.

Interventions

  • Device Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation
    Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex * Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band) * Intensity: 100% of resting motor threshold (rMT) * Location: consecutively on left and right temporo-occipital cortex (MNI: -47, -77, 4; 50, -69, -4) * Duration: 33.3 seconds for each side * Timing: Immediately before showing IAPS pictures (off-line)
  • Device Control continuous 30 Hz thetaburst transcranial magnetic stimulation
    Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex * Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band) * Intensity: 100% of resting motor threshold (rMT) * Location: consecutively on left and right superior parietal cortex (MNI: -17, -70, 60; 17, -70, 60) * Duration: 33.3 seconds * Timing: Immediately before showing IAPS pictures (off-line)

Primary outcome measures

  • Emotional valence for aversive pictures [Time frame: Immediately after the intervention, lasting for approximately 7 minutes]
Secondary outcome measures (2)
  • Emotional arousal [Time frame: Immediately after the intervention, lasting for approximately 7 minutes]
  • Aversive episodic memory [Time frame: Approximately one hour after the intervention]

Eligibility criteria

Inclusion criteria

  • Generally healthy
  • Normotensive (BP 90/60mmHg - 140/90mmHg)
  • BMI: 18 - 30 kg/m2
  • Fluent in speaking German

Exclusion criteria

  • Metal in the head area (e.g., splinters, fragments, clips, etc.)
  • Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS)
  • Cardiac pacemaker or intracardiac lines
  • Medication infusion device
  • Non removable metal piercings in the head area, pivot teeth (retainers are no exclusion criterion)
  • Tattoos (head area) less than 3 months old or older than 20 years
  • Condition after neurosurgery
  • Hearing problems or tinnitus
  • Not able to sit still due to tremor, tics, itching
  • History of repeated syncope
  • Head trauma diagnosed as concussion or associated with loss of consciousness
  • diagnosis of epilepsy, or a convulsion or a seizure in the past of the participant or his/her close family (parents and siblings)
  • TMS in the past showing problems
  • Spinal or ventricular derivations
  • Positive pregnancy test
  • Alcohol intake 12 hours before TMS visits
  • Regular intake of any medication (excluding oral contraceptives)
  • CNS-active medication or illegal drugs 48h before TMS visits
  • Individual's rMT above the limits of rTMS device
  • Suicidal tendency as measured by Montgomery-Åsberg Depression Rating Scale (MADRS), item 10 > 0

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Crossover
Masking
Single blind
Primary purpose
Basic science

Study locations

Switzerland · 1 center
  • University of Basel, Division of Cognitive Neuroscience — Basel

Identifiers

NCT: NCT07191275 · 2025-01622

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗