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Not yet recruiting NCT07189689

Mental Health Mission Mood Disorder Cohort Study

— Observational Depression - Major Depressive Disorder Depression Bipolar Treatment Resistant Depression

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Depression - Major Depressive Disorder, Depression Bipolar, Treatment Resistant Depression. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United Kingdom
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

The current study aims to understand why some people with depression respond to treatment and others do not, using markers of clinical symptoms, both clinician reported outcome measures and patient reported outcome measures, demographic information, cognitive function, genetic sequence information (genomic), chemical measures of metabolism (metabolomic), protein makeup (proteomic) and the body's natural defence system (immune/inflammatory markers) together with collections of cells that will facilitate new research to drive improvements in diagnosis and treatment of mood disorders that may be proving difficult to treat. This will allow future clinical trials within the NHS, academia and industry to drive forward new approaches and treatments. Participants who provide consent for re-contact for future treatment trials and other research studies have the potential to benefit from this with participation in experimental studies and clinical trials associated with improved patient outcomes. Overall, the cohort will generally support greater access to research opportunities for a wider population of people.

Primary outcome measures

  • PHQ-9 [Time frame: Up to 36 months.]

Eligibility criteria

Inclusion criteria

  • Those aged 18 and above
  • Primary clinical diagnosis of MDD or bipolar disorder based on DSM-5/ICD-11 diagnostic criteria
  • Participant is willing and able to give informed consent for participation in the study
  • Possesses sufficient command of the English language required to complete study requirements, as assessed by the study team

Exclusion criteria

  • Inability to complete study activities as assessed by the study team
  • Presentation requires immediate emergency treatment
  • Presentation requires clinical input not available within the research clinic

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

United Kingdom · 1 center
  • Clinical Research Facility, Warneford Hospital — Oxford

Identifiers

NCT: NCT07189689 · 18955 · 345799

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗