Effects of Adding Quercetin or Alpha Lipoic Acid to Usual Care on Symptoms and Blood Markers in Iraqi Women With Polycystic Ovary Syndrome
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Quercetin, Alpha Lipoic Acid 600 MG Oral Tablet, MetFORMIN 500 Mg Oral Tablet.
- Who it may be relevant to
- Registry conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Iraq
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Impact of Adding Quercetin or Alpha Lipoic Acid as an Adjuvant Therapy on Clinical and Biochemical Outcomes in a Sample of Iraqi PCOS Patients
Overview
This study will investigate whether the addition of Quercetin or Alpha-Lipoic Acid (ALA) to standard metformin therapy can improve symptoms, hormone levels, metabolic health, and quality of life in women with polycystic ovary syndrome (PCOS). Over 3 months, participants will be randomly assigned to one of three groups: metformin alone, metformin plus Quercetin, or metformin plus ALA. Researchers will measure changes in hormones, blood sugar, cholesterol, and antioxidant markers, as well as quality of life and medication adherence. Physical measurements and side effects will also be recorded to assess safety and overall benefit.
Detailed description
The goal of this clinical trial is to learn if adding Quercetin or Alpha-Lipoic Acid (ALA) to metformin can better treat PCOS symptoms and improve safety, metabolic health, and quality of life in women.
The main questions it aims to answer are:
* Does metformin + Quercetin or metformin + ALA improve hormonal balance (e.g., LH, FSH, testosterone) more than metformin alone? * Do these combinations enhance glycemic control (fasting glucose, insulin, HOMA-IR), lipid profiles, and oxidative-stress markers (fibulin-1, kisspeptin, SOD1, GPx)? * How do these regimens affect patient-reported outcomes like quality of life (PCOSQ) and medication adherence?
Researchers will compare three groups to see which regimen yields the greatest improvements:
* Metformin 500 mg daily alone * Metformin 500 mg + Quercetin 500 mg daily * Metformin 500 mg + ALA 600 mg SR daily
Participants will:
* Take their assigned oral treatments once daily after a meal for 3 months * Provide fasting blood samples at baseline and month 3 for hormone, glucose/insulin, lipid, and antioxidant assays * Complete the PCOSQ quality-of-life questionnaire and the 4-item Morisky adherence scale at both visits * Undergo physical measurements (weight, BMI, waist/hip circumference, blood pressure) and report any side effects
Interventions
- Drug Quercetin
Quercetin 500 mg capsule daily after meal for three months - Drug Alpha Lipoic Acid 600 MG Oral Tablet
Alpha lipoic acid 600mg SR capsule daily after meal for three months period. - Drug MetFORMIN 500 Mg Oral Tablet
metformin 500 mg daily for three months
Primary outcome measures
- Change in Hormonal Profile (LH, FSH, Testosterone) from Baseline [Time frame: Baseline and 3 months after starting assigned treatment]
- Change in Glycemic Control Markers (Fasting Glucose, Insulin, HOMA-IR) from Baseline [Time frame: Baseline and 3 months after starting assigned treatment]
Secondary outcome measures (4)
- Change in Lipid Profile (Total Cholesterol, LDL-C, HDL-C, Triglycerides) from Baseline [Time frame: Baseline and 3 months after starting assigned treatment]
- Change in Oxidative Stress and Related Biomarkers (Fibulin-1, Kisspeptin, SOD1, GPx) from Baseline [Time frame: Baseline and 3 months after starting assigned treatment]
- Change in Quality of Life (PCOSQ Total Score) from Baseline [Time frame: Baseline and 3 months after starting assigned treatment]
- Change in Medication Adherence (4-Item Morisky Scale Score) from Baseline [Time frame: Baseline and 3 months after starting assigned treatment]
Eligibility criteria
Inclusion criteria
- • Newly diagnosed patients should be at reproductive aged from 18-40 years.
- Patients diagnosed with presence of micro polycystic ovaries at ultrasound.
- Oligomenorrhea with inter-menstrual intervals longer than 35 days.
- Clinical or biochemical signs of hyperandrogenism (acne, hirsutism).
- Normal PRL levels.
Exclusion criteria
- • Presence of enzymatic adrenal deficiency and/or other endocrine disease, including diabetes.
- Other comorbidities (such as hypertension, cardiovascular disease, or hormonal dysfunction).
- Women who used oral contraceptives, hormonal therapy, or anti-lipidemic drugs.
- Pregnant women.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Iraq · 1 center
- Mustansiriyah University/ College of Pharmacy — Baghdad
Identifiers
NCT: NCT07182526 · Mustansiriyah University/ 85