Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Fluoride varnish, Novel titania nanoparticle infused fluoride varnish.
- Who it may be relevant to
- Registry conditions: Dental Plaque Accumulation, Nanoparticles, Fluoride Varnishes. Basic parameters: 16 years — 30 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Pakistan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparing the Antiplaque Efficacy of Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients-A Triple Blind Randomised Controlled Trial.
Overview
In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.
Interventions
- Procedure Fluoride varnish
Group A will receive conventional fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index. - Procedure Novel titania nanoparticle infused fluoride varnish
Group B will receive topical application of titania nanoparticle infused fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index.
Primary outcome measures
- To compare the plaque inhibitory effect of titania nanoparticle infused fluoride varnish and conventional fluoride varnish in fixed orthodontic patients. [Time frame: 6 months]
Secondary outcome measures (1)
- To measure plaque bacterial load and pH following application of titania nanoparticle infused and conventional fluoride varnish in fixed orthodontic patients. [Time frame: 6 months]
Eligibility criteria
Inclusion criteria
- Patients planned for fixed orthodontic treatment.
- Patients within age group 16-30 years.
- Patient with no history of previous orthodontic treatment.
- Patients with no active periodontal diseases.
Exclusion criteria
- Patient undergoing any antibiotic therapy.
- Patients with any craniofacial abnormality.
- Patient with mixed dentition
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Quadruple blind
- Primary purpose
- Prevention
Study locations
Pakistan · 1 center
- Pakistan Institute of Medical Sciences — Islamabad
Identifiers
NCT: NCT07180849 · SOD/ERB/2025/91