Recruiting NCT07180628
Organization and Development of Motor Cortical Circuits for Speech Production in Stuttering
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Speech Production During functional magnetic resonance imaging (MRI).
- Who it may be relevant to
- Registry conditions: Stutter, Stuttering, Adult, Stuttering, Stuttering, Developmental. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The overall objective of this study is to examine inter effector areas (IEAs) activity and functional connectivity during continuous speech production in stuttering adults.
Interventions
- Behavioral Speech Production During functional magnetic resonance imaging (MRI)
Participants will complete a speech production task with 2 conditions (stuttered, non-stuttered) while undergoing functional MRI to assess brain activity. Brain activity will be compared within subjects for the 2 conditions. The intervention is the combination of tasks delivered to all participants. The speaking task is the intervention (modifying agent) and the MRI is a measurement tool, not a therapeutic or modifying agent.
Primary outcome measures
- Blood-Oxygen-Level-Dependent (BOLD) signal change during speaking [Time frame: During the speech task (5 runs, 8 minutes each) distributed across MRI Visits 1-6, up to 12 months from enrollment.]
Eligibility criteria
Inclusion criteria
- Are between the ages of 18-65 years
- Have otherwise normal speech, language, hearing and cognition
- Speak English as their primary language
- Currently stutter
Exclusion criteria
- Have serious medical or neurological conditions (e.g., stroke, traumatic brain injury, Parkinson's disease, etc.)
- Have had a closed head injury (e.g., concussion)
- Have a reading disorder (e.g., dyslexia)
- Have hearing loss
- Have metal or electronic implants (e.g., cochlear implants, pacemakers, etc.)
- Are currently pregnant
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- University of Michigan — Ann Arbor
Identifiers
NCT: NCT07180628 · HUM00269390 · 1R01DC022763-01