A Cohort Study on Cardiovascular and Cerebrovascular Outcomes
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: ultrasound scanning.
- Who it may be relevant to
- Registry conditions: Stroke, Atheroscleroses. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Plaque-RADS Combined With Vector Flow Imaging in Assessing Carotid Atherosclerotic Risk
Overview
A standardized tool for grading carotid atherosclerotic plaques-dubbed Carotid Plaque-RADS (Reporting and Data System)-has recently been developed. Ultrasound (US) is one of the most frequently utilized methods in carotid screening worldwide. However, the clinical utility of US-based carotid plaque-RADS in refining stroke risk stratification beyond conventional stenosis grading has not been thoroughly validated. This study intends to conduct a bidirectional cohort study. In the retrospective part, we will collect relevant clinical data of patients and combine the Plaque-RADS scoring system to establish a risk regression prediction model for cardiovascular and cerebrovascular events in patients with carotid plaques. We will also prospectively collect a batch of patient data and incorporate ultrasound vector flow imaging and vascular hardness analysis to conduct a prospective cohort study, and further verify the accuracy and effectiveness of the model. Through this research, we aim to identify high-risk patients early, provide early intervention and treatment for high-risk individuals, and reduce the mortality and disability rates of cardiovascular and cerebrovascular diseases.
Interventions
- Combination product ultrasound scanning
Ultrasound (US) is one of the most frequently utilized methods in carotid screening worldwide, because of its noninvasive and radiation-free nature and advantages of cost-effectiveness and convenience。
Primary outcome measures
- the occurrence of symptomatic events [Time frame: 12 months after carotid ultrasound examinations]
Eligibility criteria
Inclusion criteria
- patients with asymptomatic carotid plaques
Exclusion criteria
- suboptimal image quality or insufficiently detailed examination affecting analysis accuracy;
- recent hemorrhagic cerebral infarction, intracranial hemorrhage, or intracranial neoplasms;
- a prior history of neck radiotherapy or ipsilateral carotid artery surgical/stent procedures;
- lost to follow-up monitoring or had an estimated survival time <12 months.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- the Third Affiliated Hospital of Sun Yat-sen University — Guangzhou
Identifiers
NCT: NCT07178015 · II2025-114-02