Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: AYA Survivors Coping and Emotional Needs Toolkit (ASCENT).
- Who it may be relevant to
- Registry conditions: Depression, Cancer, Adolescent, Young Adult. Basic parameters: 15 years — 39 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
R00 Full Factorial Trial: Optimizing ASCENT
Overview
Our team has developed a digital intervention that aims to help adolescent and young adult cancer survivors (AYAs) manage symptoms of depression. This tool includes one psychoeducation component and four components that are based on evidence-based interventions for depression. The goal of this study is to test which component or combination of components meaningfully contribute to improvements in depressive symptoms among AYAs.
Interventions
- Behavioral AYA Survivors Coping and Emotional Needs Toolkit (ASCENT)
Participants will receive access to a digital depression self-management tool (ASCENT), which aims to help AYAs manage symptoms of depression post-treatment. All users will have access to the core tool which includes daily mood tracking and a psychoeducational module about cancer and depression. Depending on assigned condition, participants will also receive access to up to 4 intervention modules which have been adapted from existing evidence-based treatments for digital delivery to AYAs through
Primary outcome measures
- Change in Depressive Symptoms during Intervention Period [Time frame: Baseline to Week 6]
Secondary outcome measures (1)
- Change in Depressive Symptoms at follow-up [Time frame: Baseline to Week 12]
Eligibility criteria
Inclusion criteria
- Age at enrollment (adolescents 15-17, emerging adults 18-25, young adults 26-39)
- Age at diagnosis (adolescents 12-17, emerging adults 15-25, young adults 15-39)
- Time since completion of treatment: 1 month to 5 years
- Language: Fluent in English (spoken and written)
- Technology: Own smart phone with data plan
Exclusion criteria
- Mental Health: Current diagnosis of severe or persistent mental illness
- Suicidality: Severe suicidal ideation (including plan and intent)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Factorial
- Masking
- Single blind
- Primary purpose
- Supportive care
Study locations
United States · 2 centers
- East Carolina University — Greenville
- Wake Forest University — Winston-Salem
Identifiers
NCT: NCT07173205 · 24-001496 · R00CA248701