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Not yet recruiting NCT07167953

The Spiral MRI Study

No phase Interventional Brain MRI

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Brain MRI, Brain MRI - SOC and spiral, Brain MRI - spiral, Brain MRI - SOC and spiral.
Who it may be relevant to
Registry conditions: Brain MRI. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

MRI Technology for Greater Efficiency and Improved Value

Overview

The goal of this clinical trial is to find out if new Magnetic Resonance Imaging (MRI) computer software will: * help make scans and exams faster * reduce artifacts * make MRI easier to understand * allow technicians to focus more on the participant and less on the scanner Participants will complete one brain MRI imaging session, lasting about 60 minutes.

Detailed description

The overall goal of this application is to design technologies that improve the value of MRI, and specifically mitigate many of the complications that negatively impact this value. The scope of MRI value is vast, but can be expressed by efficiency (high patient throughput and consistent image quality), accessibility (better scope of use and equity of availability), safety, and user experience for the patient, technologist, and interpreting physician.

Interventions

  • Device Brain MRI
    90 participants will undergo a 60 minute SOC brain MRI followed by 15 minute spiral MRI
  • Device Brain MRI - SOC and spiral
    6 participants will be scanned using 2 versions (SOC and spiral) pf 6 sequences (12 scans total).
  • Device Brain MRI - spiral
    10 participants will be scanned with 3 sequences, 3 times (9 total scans per participants)
  • Device Brain MRI - SOC and spiral
    10 participants will be scanned using 2 versions (SOC and spiral) of 6 sequences (12 scans total).
  • Device Brain MRI - spiral
    10 participants will be scanned with 3 spiral sequences to achieve desired signal to noise ratio (SNR).
  • Device Brain MRI - spiral
    5 participants will be scanned with 2 pairs of 6 spiral sequences.

Primary outcome measures

  • Image quality - decreasing scan time [Time frame: 60 minutes]
  • Image quality - tau [Time frame: 60 minutes]
  • Image quality - consistent scan time [Time frame: 60 minutes]
  • Signal to Noise Ratio (SNR) [Time frame: 60 minutes]
  • Image quality - acoustic comfort [Time frame: 60 minutes]
  • Acoustic noise [Time frame: 60 minutes]
  • Difference in Image quality [Time frame: 60 minutes]

Eligibility criteria

Healthy Controls Inclusion Criteria:

  • Adults at least 18 years
  • Able to provide written informed consent on their own behalf

Brain MR Inclusion Criteria:

  • Adults at least 18 years
  • Able to provide written informed consent on their own behalf
  • Scheduled for standard of care brain MRI

Exclusion Criteria (ALL):

  • Unable or unwilling to provide informed consent
  • Contraindication(s) to or inability to undergo MRI
  • Currently pregnant
  • Participants requiring intravenous (IV) conscious sedation for imaging are not eligible; participants requiring mild, oral anxiolytics for the clinical MRI will be allowed as long as the following criteria are met:
  • participant has their own prescription for the medication
  • informed consent process is conducted prior to the self-administration of the medication
  • they come to the research visit with a driver

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Non-randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Other

Study locations

United States · 1 center
  • University of Wisconsin - Madison — Madison

Identifiers

NCT: NCT07167953 · 2025-0948 · 1R01EB036009-01A1 · A539300 · SMPH/RADIOLOGY/RADIOLOGY · Protocol Version 6/2/2025

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗