Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Dexmedetomidine, Dexmedetomidine, Saline.
- Who it may be relevant to
- Registry conditions: Time, Dexmedetomidine, Stress Response, Laryngoscopy. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial
Overview
This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.
Detailed description
Maintaining hemodynamic stability during surgery is one of the most important tasks because good anesthesia increases the success rate of surgery and improves postoperative prognosis.
Dexmedetomidine, a potent α2-adrenoreceptor agonist, produces not only a sedative-hypnotic effect, but in situations involving cardiac risk, it also produces analgesic effects and an autonomic blocking effect, by acting on a single type of receptor.
Interventions
- Drug Dexmedetomidine
Patients will receive 0.5µg/kg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia. - Drug Dexmedetomidine
Patients will receive saline (over 10 min) 20 min before induction of anesthesia then 0.5µg/kg dexmedetomidine (over 10 min) 10 min before induction of anesthesia. - Drug Saline
Patients will receive saline before induction of anesthesia as a control group.
Primary outcome measures
- Mean arterial pressure [Time frame: Till the end of the surgery (Up to 2 hours)]
Secondary outcome measures (3)
- Heart rate [Time frame: Till the end of the surgery (Up to 2 hours)]
- Need for intraoperative fentanyl [Time frame: Intraoperatively]
- Incidence of adverse events [Time frame: 24 hours postoperatively]
Eligibility criteria
Inclusion criteria
- Age from 18 to 65 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
Exclusion criteria
- Severe cardiovascular problems.
- Respiratory disorders.
- Diabetes.
- Hypertension.
- Obesity.
- Allergic reaction to study drugs.
- Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)
- Medications that affect heart rate (HR) or blood pressure (BP).
- Pregnant.
- Currently breast-feeding women.
- History of sleep apnea.
- Those for emergency procedures.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Tanta University — Tanta
Identifiers
NCT: NCT07165483 · 36264PR1334/8/25