Menu
Not yet recruiting NCT07164326

Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients

No phase Interventional Pressor Response

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Dexmedetomidine, Saline.
Who it may be relevant to
Registry conditions: Pressor Response. Basic parameters: 18 years — 40 years · Female.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients Undergoing Caesarean Section Under General Anaesthesia

Overview

Dexmedetomidine nebulization in sever preeclamptic patients

Detailed description

Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.

Interventions

  • Drug Dexmedetomidine
    Nebulization of dexmedetomidine
  • Drug Saline
    Nebulization of normal saline

Primary outcome measures

  • Systolic blood pressure in response to endotracheal intubation [Time frame: Intraoperative]
Secondary outcome measures (3)
  • Optic nerve sheath diameter [Time frame: Intraoperative]
  • Incidence of maternal postoperative sore throat [Time frame: 1 hour Postoperative]
  • Incidence of maternal postoperative hoarseness of voice [Time frame: 1 hour Postoperative]

Eligibility criteria

Inclusion criteria

  • Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia
  • ASA II, III

Exclusion criteria

  • sever obesity (BMI ≥ 40)
  • Cardiac patients
  • History of diabetes mellitus
  • Renal dysfunction (elevated serum creatinine > 2mg\\dl)
  • hepatic dysfunction (elevated hepatic enzyme three times above normal)
  • History to hypersensitivity to the tested drug.
  • Emergency surgery
  • Known fetal anomalies

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Quadruple blind
Primary purpose
Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07164326 · Dexmedetomidine nebulization

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗