Oxytocin and Human Defensive Responses in a Dynamic Situation
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In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Oxytocin nasal spray, Placebo.
- Who it may be relevant to
- Registry conditions: Healthy. Basic parameters: 18 years — 35 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Modulatory Affect of Oxytocin on Human Defensive Responses During Dynamic Predator-prey Interactions
Overview
The presnet study is to investigate the effect of intranasal oxytocin (24 IU) treatment on modulating how human responsd to threat in a dynamic situation.
Detailed description
Predator-prey interactions are inherently dynamic, requiring adaptive responses from prey to survive. Altough there is eviedence for oxytocin modulating anxiety and fear responses to threats, it remains unclear whether oxytocin (OT) would modulate how humans respond to threats along the predatory imminence continuum to facilitate escape during such interactions. Our study therefore focuses on this question by combining behavioralmeasures, skin conductance response, and fMRI in a dynamic predator-prey interaction paradigm. In this double-blind, between-subject, placebo-controlled study, participants are instructed to escape by evaluating the relative distance between themselves (i.e., the prey), the predator (slow, medium and high attacking speed) and the refuge. The MRI and Biopac electrophysiological acquisition systems are used in the study to collect subjects' brain activity and skin conductance response. Participants are also asked to rate their confidence and anxiety levels during performing the task. We will aslo examine the resulted patterns of flight initiation distance (FID) and distance to refuge (DTR) when the prey fled from different predators. Scores of questionnaires including Positive and Negative Affect Schedule, State-Trait Anxiety Inventory, Beck Depression Inventory-Ⅱ, Autism Spectrum Quotient, Sensitivity to Punishment and Sensitivity to Reward Questionnaire, General Risk Propensity Scale are also collected before the experiment.
Interventions
- Drug Oxytocin nasal spray
intranasal administration of oxytocin (24 IU) - Drug Placebo
intranasal administration of placebo (24 IU)
Primary outcome measures
- Escape sucess rates when confronting different predators [Time frame: 1 hour]
- Flight initiation distance [Time frame: 1 hour]
- The distance to refuge [Time frame: 1 hour]
- Brain activity patterns in response to threats along the predatory imminence continuum [Time frame: 1 hour]
Secondary outcome measures (3)
- Confidence rating scores [Time frame: 1 hour]
- Anxiety rating scores [Time frame: 1 hour]
- SCR during task [Time frame: 1 hour]
Eligibility criteria
Inclusion criteria
- Healthy subjects without past or current psychiatric or neurological disorders
Exclusion criteria
- History of head injury; pregnant, menstruating, taking oral contraceptives; medical or psychiatric illness,
- The presence of metal in the body or claustrophobia.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Basic science
Study locations
China · 1 center
- University of Electronic Science and Technology of China — Chengdu
Identifiers
NCT: NCT07162584 · UESTC-neuSCAN-87