Peripheral Nerve Activation Sensitivity
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Electric and electromagnetic stimulation.
- Who it may be relevant to
- Registry conditions: Nerve Excitation Sensitivity. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Switzerland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Peripheral Nerve Activation Sensitivity to Electromagnetic and Electrical Stimulation in the Upper Arm
Overview
Volunteers will undergo various peripheral nerve stimulations (electric, electromagnetic, and temporal interference) to evaluate each method's sensitivity. The main objective is to examine the relationship between nerve activation and coil placement relative to the nerve, as well as how different coil types influence maximal nerve activation.
Interventions
- Device Electric and electromagnetic stimulation
Application of electromagnetic and electric stimulation using coils of different designs and electrodes to assess peripheral nerve sensitivity. The stimulation is momentary, non-therapeutic, and performed for basic science research purposes
Primary outcome measures
- Maximum nerve activation response to electromagnetic stimulation with different coils [Time frame: Day 1]
Secondary outcome measures (3)
- Spatial range of nerve activation with electromagnetic coils [Time frame: Day 1]
- Spatial range of nerve activation with neuromuscular electrical stimulation electrodes (NMES) [Time frame: Day 1]
- Amplitude ratios of temporal interference stimulation (TIS) electrodes associated with nerve activation [Time frame: Day 1]
Eligibility criteria
Inclusion criteria
- Person aged > 18 years
- Signed informed consent
- Healthy
- Willingness and ability to adhere to study procedures
Exclusion criteria
- Known hypersensitivity to electric or electromagnetic stimulation
- Any implanted metal or electronic device in the upper body (except dental work such as fillings or braces), e.g., active medical devices, metal implants
- Neurological or neuromuscular disorders or conditions
- History of seizures or epilepsy
- Current treatment with drugs that lower seizure threshold (e.g., certain analgesics, methylxanthines, antipsychotics, antidepressants, antiepileptics, anesthetics)
- Pregnancy or breastfeeding
- Surgical intervention of the arm within the last 4 weeks
- Allergy to adhesives or ultrasound gel components (e.g., polyethylene glycols)
- Skin lesions, infections, or strictures in the arm region
- Tattoos on the stimulated (right) arm and hand, or in any area likely to be captured in video recordings
- Inability to follow study procedures (e.g., due to language barrier, psychological disorders, dementia)
- Participant deprived of liberty by administrative or judicial decision or under legal guardianship
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Switzerland · 1 center
- Institute for Human Centered Engineering HuCE — Biel
Identifiers
NCT: NCT07160413 · 2025-00776 · 108.018 IP-LS