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Recruiting NCT07158736

Genicular Nerve Block for Knee Pain in the ED

No phase Interventional Knee Pain

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Genicular nerve block with bupivacaine and corticosteroids, Standard of Care.
Who it may be relevant to
Registry conditions: Knee Pain. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Ultrasound-Guided Genicular Nerve Block for Knee Pain in the Emergency Department: A Randomized Controlled Trial

Overview

Patient with atraumatic knee pain without a large knee effusion on x-ray will be randomized to receive either a genicular nerve block (GNB) or standard of care in the emergency department.

Interventions

  • Procedure Genicular nerve block with bupivacaine and corticosteroids
    genicular nerve block with ideal body-weight dosing of bupivacaine 0.5% with 4 mg dexamethasone
  • Other Standard of Care
    This involves standard of care pain relief for patients who do not receive the genicular nerve block for knee pain, such as acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), and opioids.

Primary outcome measures

  • Pain level [Time frame: 1 hour post-enrollment]
Secondary outcome measures (3)
  • Difference in Duration of Analgesia [Time frame: 24 hours]
  • Difference in AP-POQ-RED score [Time frame: 1 hour after enrollment]
  • Difference in length of stay in the emergency department [Time frame: Average 1 hour]

Eligibility criteria

Inclusion criteria

  • Atraumatic knee pain
  • >17 years age
  • X-ray of the knee obtained in the ED
  • Initial pain score (numeric rating scale) 5-10

Exclusion criteria

  • Fracture or dislocation on x-ray
  • large knee joint effusion identified on x-ray
  • allergy or contraindication to local anesthetics
  • History of local anesthetic systemic toxicity after receiving local anesthetics
  • Pregnancy
  • Incarcerated
  • History of knee replacement of affected knee
  • Concern for septic joint
  • Overlying cellulitis
  • Hemodynamic instability
  • Altered mental status or inability to consent for procedure.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Treatment

Study locations

United States · 4 centers
  • Hospital of the University of Pennsylvania — Philadelphia
  • Pennsylvania Hospital — Philadelphia
  • Pennsylvania Presbyterian Medical Center — Philadelphia
  • HUP Cedar — Philadelphia

Identifiers

NCT: NCT07158736 · IRB Protocol #858259

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗