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Recruiting NCT07155941

Ecological Momentary Intervention for Reward in Anhedonia

No phase Interventional Anhedonia Anxiety Stress Depression

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Training of reward processing/sensitivity, Relaxation Training (PMR), Psychoeducation.
Who it may be relevant to
Registry conditions: Anhedonia, Anxiety, Stress, Depression. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Germany
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Overview

The present study evaluates a two week ecological momentary intervention (EMI) in reducing anhedonia and psychological distress (i.e. elevated depression, stress and anxiety). Participants in the experimental group complete three daily exercises targeting reward-related processes, including positive mental imagery, savoring, gratitude, taking ownership for positive experience, and silver lining. These components were selected to improve reward anticipation as well as reward consumption and reward learning as the underlying mechanisms of anhedonia. An active control group receives progressive muscle relaxation training, matched in format and frequency. Exercise units are presented using audio recordings via smartphone app.

Detailed description

Anhedonia, the diminished ability to experience positive emotions such as pleasure, is a clinically relevant condition central to depression and frequently observed across a range of other psychological disorders including anxiety disorders or chronic stress. Despite its prevalence and impact on quality of life, effective interventions specifically targeting anhedonia remain limited. Standard cognitive-behavioral therapies (CBT) often reduce negative affect (e.g., sadness, anxiety) but tend to be less effective in enhancing positive affect. Moreover, anhedonia has been proposed as a potential limiting factor in the efficacy of exposure-based treatments for anxiety disorders, underscoring the need for low-threshold interventions that directly target reward-related deficits.

At the core of anhedonia lies impaired reward processing, which involves multiple phases: (1) reward anticipation (wanting), (2) reward consumption (liking), and (3) reward-based learning. Individuals with elevated anhedonia often show deficits across these domains, leading to reduced engagement in rewarding activities and motivational impairments. Therefore, effective interventions should aim to strengthen these specific facets of reward functioning.

Emerging approaches such as Positive Affect Treatment (PAT) have demonstrated promising effects by combining components like positive mental imagery, savoring, self-reinforcement (i.e., taking ownership of positive experiences), and cognitive reframing (e.g., silver lining techniques). Complementary evidence suggests that gratitude-based interventions can enhance well-being and buffer against stress, based on the idea that gratitude and negative affect are partially incompatible.

Building on these findings, the current study tests a two-week ecological momentary intervention (EMI) designed to enhance reward processing and reduce anhedonia in daily life. The intervention is delivered via the smartphone app m-Path and comprises three brief training units per day. These include a combination of audio-guided exercises and ecological momentary assessments (EMA) capturing mood, activity, and psychological symptoms. The exercises target positive mental imagery, savoring, gratitude, silver lining, and taking ownership of positive experiences-each mapped onto distinct components of reward processing. EMI formats offer the advantage of flexibility and integration into everyday contexts without requiring direct clinician contact.

Participants are randomly assigned to either the reward-focused intervention group or an active control group. The control group receives a structurally equivalent two-week training consisting of progressive muscle relaxation (PMR) exercises, also delivered via the m-Path app. PMR is an established stress-reduction technique and serves as an active comparator matched in format, frequency, and duration. The control group completes two audio-guided PMR sessions per day and one brief reflection unit each evening.

It is hypothesized that the reward intervention will (a) reduce anhedonia and psychological distress more effectively than PMR and (b) lead to specific improvements in reward processing.

Interventions

  • Behavioral Training of reward processing/sensitivity
    Participants in the experimental group complete a two-week ecological momentary intervention (EMI) consisting of three brief training units per day, each delivered via a smartphone. The exercises target different aspects of reward processing and are scheduled at specific times throughout the day. The morning unit (to be completed between 10:00 and 12:00 a.m.) involves a positive mental imagery task guided by audio recording. Participants are guided to vividly imagine a future situation with the
  • Behavioral Relaxation Training (PMR)
    Participants in the control group complete a two-week progressive muscle relaxation (PMR) program designed to match the reward training in both frequency and duration. The intervention consists of three daily units, each delivered via a smartphone app and guided by audio recordings. The first and second units of each day consist of short audio-guided PMR sessions (approximately 5 minutes each). These exercises systematically guide participants through alternating tension and relaxation of diffe
  • Other Psychoeducation
    All participants receive a psychoeducation session on the day before the respective intervention starts. In this session, a graduate-level study team member introduces the rationale behind the training (PMR or reward-training), and demonstrates each exercise. Participants also practice each task.

Primary outcome measures

  • Change in anhedonia/hedonic capacity; measured with the Snaith-Hamilton Pleasure Scale (SHAPS) from baseline to post-intervention and baseline to 3-months follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Change in depression, anxiety and stress; measured with the Depression-Anxiety-Stress-Scale (DASS-21) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
Secondary outcome measures (12)
  • Change in anhedonia; measured with the Dimensional Anhedonia Rating Scale (DARS) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Change in reward sensitivity and procession; measured with the Positive Valence System Scale-21 (PVSS-21) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Trait-Positive Emotionality (PE) and its change as measured with the NEO-Five-Factor (NEO-FFI) Positive-Emotionality-Subscale from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Positive and negative affect and their changes; measured with the Positive and Negative Affect Schedule (PANAS) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Change in social anxiety; measured with the Social Phobia Inventory (SPIN) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Change in social anxiety; measured with the Social Interaction Anxiety Scale (SIAS) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Imagination abilities; measured with the Spontaneous Use of Imagery Scale (SUIS) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Vividness of mental images; measured with the Plymouth Sensory Imagery Questionnaire (PSI-Q) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Changes in feeling gratitude; measured with the Gratitude Questionnaire-Five-German (GQ-5-G) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Changes in perseverative thinking; measured with the Perseverative Thinking Questionnaire (PTQ) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Changes in use of emotion regulation strategies; measured with the Emotion Regulation Questionnaire (ERQ) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]
  • Changes in feeling overall relaxed (single self-composed visual analog scale item) from baseline to completion and baseline to follow-up [Time frame: Baseline, 2 weeks (completion of intervention) and 3 months]

Eligibility criteria

Inclusion criteria

  • German speaking
  • Smartphone available and willingness to participate in repeated training units and questions delivered via app
  • Clinically elevated anhedonia (SHAPS >= 25) and elevated depression (DASS-21-Depression >= 10), elevated anxiey (DASS-21-Anxiety >= 6) or elevated stress (DASS-21-Stress >= 10)

Exclusion criteria

  • Psychotropic medication
  • Psychotherapy currently ongoing or planned during participation
  • Suicidality, lifetime diagnosis of bipolar disorders or psychotic episodes

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Germany · 1 center
  • Philipps-University Marburg — Marburg

Identifiers

NCT: NCT07155941 · EMIRA

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗