Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Coronary Angiographic Assessment.
- Who it may be relevant to
- Registry conditions: Triglycerides Glucose Index, Angiographic Profiling, Non-Diabetic, Premature. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Impact of Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients
Overview
This study aims to evaluate the impact of the triglyceride-glucose (TyG) index on the angiographic profiling of non-diabetic patients with premature coronary artery disease (CAD).
Detailed description
Premature coronary artery disease (CAD), defined as CAD occurring before the age of 55 in men and 65 in women, has emerged as a growing health concern worldwide.
Insulin resistance and associated metabolic alterations are strongly implicated in premature atherosclerosis. Even in non-diabetic individuals, subclinical insulin resistance promotes endothelial dysfunction, oxidative stress, and low-grade inflammation, leading to early vascular damage.
The triglyceride-glucose (TyG) index, calculated using fasting glucose and triglyceride levels, has emerged as a cost-effective surrogate marker for insulin resistance.
Interventions
- Other Coronary Angiographic Assessment
Coronary angiographic assessment will be performed for all patients.
Primary outcome measures
- Incidence of ischemia- driven revascularization [Time frame: 6 months post-procedure]
Secondary outcome measures (4)
- Association between triglyceride-glucose index and single-vessel disease [Time frame: 6 months post-procedure]
- Association between triglyceride-glucose index and two-vessel disease [Time frame: 6 months post-procedure]
- Association between triglyceride-glucose index and three-vessel disease [Time frame: 6 months post-procedure]
- Correlation of the triglyceride-glucose index with traditional cardiovascular risk factor [Time frame: 6 months post-procedure]
Eligibility criteria
Inclusion criteria
- Age ≥18 years old.
- Both sexes.
- Non-diabetic patients \[no history of diabetes, hemoglobin A1C (HbA1C) < 6.5%, fasting glucose < 126 mg/dL\].
- Confirmed diagnosis of coronary artery disease (CAD) by coronary angiography.
Exclusion criteria
- Known diabetes mellitus (type 1 or type 2).
- Previous history of coronary revascularization.
- Severe hepatic or renal dysfunction \[alanine transaminase (ALT)/aspartate aminotransferase (AST) ≥ 5× upper limit of normal (ULN), estimated glomerular filtration rate (eGFR)< 30 mL/min/1.73 m²\].
- Malignant disease, autoimmune disease, or systemic inflammatory disorders.
- Current use of triglyceride-lowering medications.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Sohag University — Sohag
Identifiers
NCT: NCT07154186 · Soh-Med-25-5-5PD