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Recruiting NCT07146698

No Sedation Versus Daily Interruption of Sedation in Chronic Obstructive Pulmonary Disease Mechanically Ventilated Patients- A Prospective Study

— Observational Chronic Obstructive Pulmonary Disease (COPD) Sedation and Analgesia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: daily Interruption of Sedation.
Who it may be relevant to
Registry conditions: Chronic Obstructive Pulmonary Disease (COPD), Sedation and Analgesia. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Egypt
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

this study is to compare no-sedation versus daily interruption of sedation (DIS) in Chronic obstructive pulmonary disease (COPD) patients receiving mechanical ventilation upon the ventilator-free days.

Interventions

  • Behavioral daily Interruption of Sedation
    The patients will be managed by DIS. Richmond agitation and sedation score (RASS) will be used for monitoring the depth of sedation

Primary outcome measures

  • Ventilator-free days [Time frame: from day-1 to day-28)]

Eligibility criteria

Inclusion criteria

  • Patients of both sex aged 18 years or older
  • The study will include 60 patients divided into 2 equal groups
  • Invasive mechanical ventilation
  • Patients with COPD patients (post-bronchodilator FEV1/FVC< 70, and under follow through the department outpatient clinic) exacerbation admitted to the ICU and required invasive mechanical ventilation were recruited.

Exclusion criteria

Allergy to sedative which will be used

  • renal or hepatic impairment
  • proven or suspected psychiatric or neurological impairment
  • pregnancy

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Case-control

Study locations

Egypt · 1 center
  • Benha University Hospitals — Banhā

Identifiers

NCT: NCT07146698 · MD 9-11-2024

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗