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Recruiting NCT07140757

Radiofrequency Ablation for Management of Benign/Indeterminate Thyroid Nodules and Low Risk Papillary Thyroid Cancers

— Observational Low Risk Papillary Thyroid Cancer Radiofrequency Ablation

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Questionnaire.
Who it may be relevant to
Registry conditions: Low Risk, Papillary Thyroid Cancer, Radiofrequency Ablation. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

To track the outcomes of patients who have been treated with RFA and its long-term effectiveness, and to learn more about the quality of life of patients who have received RFA in this study.

Detailed description

Primary Objectives

• To evaluate thyroid nodule volume changes over time in participants undergoing RFA as part of clinical care

Secondary Objectives

* To establish the health-related quality of life among participants undergoing with ultrasound guided RFA. * To evaluate the sonographic features of thyroid nodules over time following ultrasound guided RFA. * To assess adverse events rates following ultrasound guided RFA.

Interventions

  • Other Questionnaire
    This questionnaire includes twenty-four questions covering patients complaints ranging from 0 to 4. Patients will be asked about the presence and severity of each item currently on the medical appointment.

Primary outcome measures

  • Health- related Quality of Life Questionnaires [Time frame: Through study completion; an average of 1 year]

Eligibility criteria

Eligibility Criteria

  • Participants scheduled to undergo ultrasound-guided RFA for the following conditions: benign thyroid nodules, indeterminate thyroid nodules, low-risk DTC, and recurrent PTC
  • Participant is over 18 years and is either not a surgical candidate or has declined surgery.
  • Capable and willing to provide written informed consent
  • Participant has one of the following diagnoses:
  • Biopsy-proven benign thyroid nodules causing compressive and/or cosmetic symptoms who are requesting treatment,
  • Biopsy-proven indeterminate nodules (AUS or follicular neoplasm)
  • Papillary thyroid carcinoma (PTC) without metastasis
  • Locally recurrent thyroid cancer (< 2 cm).

Exclusion criteria

  • Participants meeting any of the following criteria will be excluded:
  • Participants considered unsuitable for RFA by the treating physician

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

United States · 1 center
  • MD Anderson Cancer Center — Houston

Identifiers

NCT: NCT07140757 · 2025-0083 · NCI-2025-06179

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗