High-Frequency QRS for Predicting Microvascular Dysfunction and Adverse Events After PCI in Acute Myocardial Infarction
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: High-Frequency QRS.
- Who it may be relevant to
- Registry conditions: AMI. Basic parameters: 18 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
High-Frequency QRS for Predicting Microvascular Dysfunction and Adverse Events After PCI in Acute Myocardial Infarction: A Prospective, Multicenter Cohort Study
Overview
This observational study aimed to investigate the prognostic value of high-frequency QRS (HF-QRS) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI), as well as its potential role in diagnosing microvascular dysfunction. The main question it aims to answer is: 1. Whether HF-QRS could serve as an effective tool for early identification of high-risk AMI patients and prognosis prediction; 2. Whether HF-QRS provides auxiliary diagnostic value for post-AMI microvascular dysfunction. Participants underwent HF-QRS assessment and were prospectively followed for 1 year to record the incidence of major adverse cardiovascular events (MACE).
Interventions
- Device High-Frequency QRS
All enrolled patients underwent HF-QRS assessment, with subsequent recording of MACE to evaluate the predictive value of HF-QRS parameters for clinical outcomes
Primary outcome measures
- To evaluate the predictive value of high-frequency QRS (HF-QRS) parameters for major adverse cardiovascular events (MACE) within 1 year after PCI in AMI patients and to construct a prognostic risk prediction model. [Time frame: 12 months]
Secondary outcome measures (1)
- To evaluate the adjunctive diagnostic value of high-frequency QRS parameters for microvascular dysfunction in ACS patients following percutaneous coronary intervention [Time frame: 12 months]
Eligibility criteria
Inclusion criteria
- Aged 18 to 75 years (inclusive)
Diagnosed with acute myocardial infarction (AMI, including STEMI and NSTEMI) and underwent successful emergency PCI
Voluntarily participated and provided written informed consent
Exclusion criteria
- History of prior myocardial infarction or chronic heart failure
QRS duration >120 ms (including paced rhythm, WPW syndrome, bundle branch block, or left ventricular hypertrophy with repolarization abnormalities)
Structural heart disease (congenital heart disease, cardiomyopathy, aortic dissection, etc.)
Persistent atrial fibrillation or malignant arrhythmias
History of cerebral hemorrhage or ischemic stroke within 1 month
Prolonged cardiopulmonary resuscitation or requiring advanced life support (IABP/ECMO, etc.)
Scheduled for imminent surgery with anticipated inability to complete HF-QRS assessment
Other life-threatening conditions including: Severe hepatic or renal dysfunction;Uncontrolled systemic diseases;Hematologic disorders;Active infections;Malignancy with life expectancy <1 year Other investigator-determined exclusionary conditions:Pregnancy;Concurrent participation in other clinical trials
Refusal to participate in the clinical study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- The Affiliated Hospital of Xuzhou Medical University — Xuzhou
Identifiers
NCT: NCT07138638 · XYFY2025-KL303-01