Psychological Options for Wellness and Recovery (POWeR) Trial for Veterans With Chronic Back/Neck Pain

The current leading psychotherapeutic treatment for chronic pain is cognitive behavioral therapy (CBT-CP), which has been found to be safe and modestly efficacious in the treatment of chronic back or neck pain (CBNP). The fundamental goal of CBT-CP is to encourage participants to adopt an active, problem-solving approach to managing the challenges associated with chronic pain. CBT-CP intervention follows a standard structure of 9 sessions with the following objectives: 1) reducing the negative impact of pain on daily life 2) improving physical and emotional functioning 3) increasing effective coping skills for managing pain 4) reducing pain intensity. Recent evidence shows CBT provides a 1-1.5 point reduction in pain intensity on an 11-point pain scale when compared to treatment as usual.

Using advances in neuroscience and psychology, investigators recently developed a novel psychological treatment called Pain Reprocessing Therapy (PRT). Using a combination of cognitive, exposure-based, and somatic psychotherapy techniques, PRT aims to promote patients' reconceptualization of pain as due to reversible, non-dangerous brain activity rather than peripheral pathology. Critically, PRT aims to reduce or eliminate pain, rather than merely increase functioning.

In the first trial of PRT (N = 151), 66% of patients randomized to PRT were pain-free or nearly pain-free at post-treatment, compared to fewer than 20% of those in the placebo and usual care control groups. PRT has several critical conceptual distinctions from CBT including different approaches to pain subtyping, a different understanding of chronic pain etiology, differing treatment goals (recovery vs. improved functioning), and a different focus on non-pain psychosocial threats. Given the conceptual differences and early existing promising efficacy data of PRT, a critical next step to achieve practical improvements in Veteran health is a comparative effectiveness trial of PRT vs. CBT in a Veteran Affairs (VA) clinic, utilizing VA clinicians, VA treatment infrastructure, and Veteran participants.

Aim 1 of this study is to test the comparative effectiveness of PRT to CBT and usual care on pain severity (primary outcome) for veterans with CBNP at post-treatment (primary endpoint) and one year follow-up.

Aim 2 of this study is to test the comparative effectiveness of PRT to CBT and usual care on secondary patient-reported outcomes measuring core outcome domains, quality of life, and opioid medication use.

Aim 3 of this study is to identify key barriers and facilitators of PRT response in a Veteran population using qualitative methods in a subsample of participants (n = 40) and in clinicians learning PRT.

• Pain Interference [Time frame: Post-treatment (at an average of 10 weeks) and 26, 39, and 52 weeks post-randomization]
• Satisfaction with Life [Time frame: Post-treatment (at an average of 10 weeks) and 26, 39, and 52 weeks post-randomization]
• Depression [Time frame: Post-treatment (at an average of 10 weeks) and 26, 39, and 52 weeks post-randomization]
• Anxiety [Time frame: Post-treatment (at an average of 10 weeks) and 26, 39, and 52 weeks post-randomization]
• Fatigue [Time frame: Post-treatment (at an average of 10 weeks) and 26, 39, and 52 weeks post-randomization]
• Post-Traumatic Stress Disorder (PTSD) Symptoms [Time frame: Post-treatment (at an average of 10 weeks) and 26, 39, and 52 weeks post-randomization]
• Client satisfaction [Time frame: Post-treatment (at an average of 10 weeks) and 26, 39, and 52 weeks post-randomization]
• Medication Use [Time frame: Post-treatment (at an average of 10 weeks) and 26, 39, and 52 weeks post-randomization]