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Not yet recruiting NCT07136831

"Short-term Outcome in STEMI Patients Undergoing Primary PCI: A Comparative Study Between Rural and Urban Communities at Assiut University."

— Observational MACE In STEMI

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Primary Percutaneous Coronary Intervention (PPCI).
Who it may be relevant to
Registry conditions: MACE, In STEMI. Basic parameters: 18 years — 90 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

"Short-term Outcome of Patients From Rural Versus Urban Communities Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction"

Overview

this study aims to assess the short-term (3-month) clinical and echocardiographic outcomes of primary PCI among STEMI patients from rural versus urban areas in Upper Egypt. A special focus will be placed on identifying predictors of MACE. The findings may offer valuable insight into optimizing STEMI care pathways and support the development of regional STEMI networks across Egypt.

Detailed description

ST-segment elevation myocardial infarction (STEMI) is a life-threatening condition that requires urgent reperfusion therapy, with primary percutaneous coronary intervention (PCI) being the gold standard of care. While PCI significantly reduces complications and improves survival, access to this intervention remains unequal, particularly between rural and urban populations

According to the latest census definitions, a rural area is characterized by:A population of fewer than 5,000,A population density of less than 400 persons per square kilometer,And more than 25% of the male working population engaged in agriculture.

Rural patients often experience delayed diagnosis, limited access to PCI-capable centers, and prolonged ischemic times. These factors contribute to poorer clinical outcomes, including higher rates of reinfarction, heart failure, and mortality. In contrast, urban residents typically have faster access to specialized cardiac care and more efficient treatment pathways.

In Upper Egypt, this urban-rural gap is particularly pronounced, with rural patients facing substantial logistical and systemic challenges in receiving timely PCI. Although efforts have been made to expand PCI access nationwide, there remains a lack of localized data comparing short-term outcomes-particularly major adverse cardiovascular events (MACE)-between rural and urban STEMI patients.

Interventions

  • Device Primary Percutaneous Coronary Intervention (PPCI)
    A catheter-based invasive procedure used to open blocked coronary arteries in patients presenting with ST-elevation myocardial infarction (STEMI).

Primary outcome measures

  • Incidence of major adverse cardiovascular events (MACE) among STEMI patients undergoing primary percutaneous coronary intervention (PCI), [Time frame: 3 month]

Eligibility criteria

Inclusion criteria

  • 1\. Adults aged ≥18 years. 2. Confirmed diagnosis of ST-segment elevation myocardial infarction (STEMI) based on ECG and cardiac biomarkers.

3\. Underwent primary percutaneous coronary intervention (PCI) within the study period.

4\. Known and verified residential address classified as rural or urban based on official definitions (e.g., UK or WHO classification).

5\. Informed consent obtained

Exclusion criteria

  • Non-STEMI or unstable angina cases.
  • Patients who received fibrinolytic therapy instead of PCI.
  • Transfer from another facility after more than 12 hours of symptom onset.
  • Patients with previous revascularization (e.g., CABG or PCI within the last 6 months).
  • Incomplete clinical data or unknown residential location.

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Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07136831 · STEMI-PPCI-RURALURBAN-ASU25

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗