Vaped Phenanthrene
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: D10-phenanthrene.
- Who it may be relevant to
- Registry conditions: Former Smoker, Non-Smoker. Basic parameters: from 21 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Investigating Vaped Phenanthrene Biomarkers in Former Smokers
Overview
Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former smokers through more harmful pathways than never-smokers. If former smokers break down chemicals that enter their lungs through more harmful pathways this might be putting them at higher risk for developing lung cancer even though they quit smoking. This information may help find better ways to prevent or treat cancer in the future. This study is under an IND, but the drug is not being studied; instead, it is being used as a marker for drug metabolism.
Interventions
- Other D10-phenanthrene
All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons \[PAHs\].
Primary outcome measures
- Urinary Ratio of D10PheT/D9PhOH [Time frame: 24 hours after vaping phenanthrene]
- TNE [Time frame: Baseline measure]
Eligibility criteria
Inclusion criteria
- > 21 years of age
- In good physical \& mental health
- In stable physical \& mental health
- Have tried vaping
- Former daily cigarette smokers who quit 1-20 year ago
- Non-smokers who have not used tobacco or nicotine products
Exclusion criteria
- Has any respiratory disease (ex - asthma, COPD, etc...)
- Has/had high blood pressure
- Has/had liver disease
- Has/had cancer
- Has experience negative effects when vaped previously
- Pregnant or nursing
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- University of Minnesota — Minneapolis
Identifiers
NCT: NCT07134426 · 2022LS127