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Not yet recruiting NCT07132151

Reinforcement Learned Automated Anesthesia Systems During Painless Abortion

No phase Interventional Painless Abortion Artificial Intelligence (AI) Ciprofol

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: AI Controlled General Anesthesia, General Anesthesia.
Who it may be relevant to
Registry conditions: Painless Abortion, Artificial Intelligence (AI), Ciprofol. Basic parameters: 18 years — 45 years · Female.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Automated Anesthesia Systems for Painless Abortion (AAS-PA): a Multi-center, Randomized Controlled Trial

Overview

This study compares the automated anesthesia systems for painless abortion (AAS-PA) with traditional anesthesia in painless abortions. It assesses intraoperative indicators (hypoxemia, injection pain, hypotension, hemodynamics, respiratory depression) and postoperative outcomes (nausea, dizziness, recovery time, satisfaction). The AAS-PA group uses AI-adjusted intravenous ciprofol based on real-time vital signs and sedation depth; the traditional group relies on manual anesthesia. The goal is to verify if AAS-PA safely manages sedation, meets painless standards, reduces adverse events, and improves experience, aiding optimized automated protocols.

Interventions

  • Procedure AI Controlled General Anesthesia
    During painless abortion, anesthesia will be induced using ciprofol, and controlled by an AI model.
  • Procedure General Anesthesia
    Anesthesia will be induced using ciprofol, and controlled by experienced anesthesiologists.

Primary outcome measures

  • Incidence of Hypoxemia [Time frame: During procedure]
Secondary outcome measures (10)
  • Area under curve of hypoxemia [Time frame: During procedure]
  • Duration of colonoscopy [Time frame: During procedure]
  • Lowest value of blood oxygen saturation [Time frame: During procedure]
  • Induction and maintenance doses of anesthesia [Time frame: During procedure]
  • Ciprofol related adverse reactions [Time frame: During procedure]
  • Induction time [Time frame: During procedure]
  • Complete recovery time [Time frame: During procedure]
  • Incidence of hypotension [Time frame: During procedure]
  • Counts of body movement [Time frame: During procedure]
  • Dose of norepinephrine [Time frame: During procedure]

Eligibility criteria

Inclusion criteria

  • Age between 18-45 years
  • ASA status Ⅰ to Ⅱ
  • Diagnosed with early intrauterine pregnancy
  • Body mass index (BMI) between 18 to 28 kg/m2

Exclusion criteria

  • History of cardiac, hepatic, renal, or metabolic disorders (e.g., diabetes, hypertension, sleep apnea)
  • Known allergy to opioids or ciprofloxacin components
  • Cachexia
  • History of substance or alcohol abuse
  • ASA class III or higher
  • Participation in any other drug clinical trial within the past 3 months
  • Long-term use of sedative or analgesic medications
  • History of neurological disorders and convulsions

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Double blind
Primary purpose
Treatment

Study locations

China · 8 centers
  • Fujian Provincial Hospital — Fuzhou
  • Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian) — Jinjiang
  • Shishi Hospital — Quanzhou
  • Peking University Shenzhen Hospital — Shenzhen
  • Zhengzhou Central Hospital Affiliated to Zhengzhou University — Zhengzhou
  • Sichuan Provincial People's Hospital — Chengdu
  • The First Affiliated Hospital of Army Medical University — Chongqing
  • The People's Hospital of Yubei District of Chongqing city — Chongqing

Identifiers

NCT: NCT07132151 · SZUS2025002

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗