Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Alzheimer Disease, Mini-Mental State Examination, Cognitive Dysfunction, Neuropsychological Tests. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study looks at people with Alzheimer's disease to find out which factors are linked to their initial score on the Mini-Mental State Examination (MMSE) and which factors may predict a fast decline in their score over 12 months. Researchers will review medical records from patients seen at the Memory Clinic of Gonesse Hospital and analyze information such as age, education, medical history, nutrition, mood, and caregiver burden. The goal is to better understand what influences early cognitive performance and how quickly it changes, to help improve patient care and planning.
Primary outcome measures
- Change in MMSE Score Over 12 Months - measured as either a decrease of ≥3 points on the Mini-Mental State Examination [MeSH] or patient institutionalization within 12 months. [Time frame: 12 months]
Eligibility criteria
Inclusion criteria
- Confirmed diagnosis of Alzheimer's disease according to NIAA 2018 or IWG 2021 criteria
- At least two MMSE evaluations spaced 12 months apart
- Follow-up at the Memory Clinic of CH Gonesse
Exclusion criteria
- Presence of other neurodegenerative diseases (e.g., Frontotemporal Dementia, Multiple System Atrophy, Vascular Dementia, LATE)
- Patient has moved out of the study area (outside the CH Gonesse territory)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- Centre Hospitalier de Gonesse — Gonesse
Identifiers
NCT: NCT07122856 · 0114_NEUROLOGIE_TARGET MMSE