EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: saliva a a diagnostic tool for early detection of oral cancer.
- Who it may be relevant to
- Registry conditions: The Study Focuses on the Saliva as Potential Source of Early Detection of Oral Cancer. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Pakistan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Saliva as Early Detection Tool for Oral Cancer
Overview
Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing. Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.
Detailed description
The project aims to evaluate salivary cytology, genes and biochemistry of the healthy normal population and compare it with that of the oral submucous fibrosis and oral cancer. For salivary experiments 3 cc of fresh saliva will be collected and analysed.
Interventions
- Diagnostic test saliva a a diagnostic tool for early detection of oral cancer
Three groups will be compared on the basis of cytology, genes and biochemical analysis
Primary outcome measures
- salivary cytology [Time frame: 1 year]
- evaluation of telomere length of salivary cells [Time frame: 1 year]
- evaluation of biochemicals of saliva [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- healthy volunteers
- patients with oral submucous fibrosis
- patients with biopsy proven oral cancer
Exclusion criteria
- patients with oral infection
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Pakistan · 1 center
- Medical Research Center — Jāmshoro
Identifiers
NCT: NCT07122128 · SalivaP01 · Sal001