Recruiting NCT07118137
Memory Deterioration in Alzheimer Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: 7T MRI, EEG, Blood samples, Stool samples.
- Who it may be relevant to
- Registry conditions: Alzheimer Disease, Neurodegenerative Diseases, Magnetic Resonance Imaging, Memory Impairment. Basic parameters: from 55 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Norway
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Translational Neuroscience CAG for Alzheimer's Disease
Overview
Semantic AD
Interventions
- Device 7T MRI
Resting and activity-based MRI. Dring activity based MRI, the participant will complete tasks testing semantic memory. - Device EEG
Resting-state EEG - Biological Blood samples
Blood samples taken for analysis of central blood biomarkers. - Biological Stool samples
Stool samples collected to identify distinct gut-microbiota compositions between the groups. - Diagnostic test Neuropsychologic test (MoCA)
Map cognition with clinically well-established neuropsychology test
Primary outcome measures
- Understand which individual differences are observed among patients with Alzheimer's disease (AD). [Time frame: From enrollment to end of follow-up at 1 year.]
- Compare changes in the brain, blood, and stool samples between dementia patients and healthy controls. [Time frame: From project enrollment to end of follow-up at 1 year.]
Secondary outcome measures (1)
- Understand which individuals with mild cognitive impairment (MCI) go on to develop Alzheimer's disease (AD). [Time frame: From enrollment to the end of follow-up time at 1 year.]
Eligibility criteria
Inclusion criteria
- Confirmed diagnosis based on current ICD criteria for AD or MCI .
- >55years.
- Norwegian native speaker
- Lives at home and not in a health institution
Exclusion criteria
- Patients with severe cognitive impairment that prevents assessment with the selected modalities (planned cut-off: CDR > 2).
- Presence of brain tumors.
- History of traumatic brain injury.
- History of cranial surgery.
- Contraindications to the selected imaging modalities (e.g., 7T MRI or EEG).
- Diagnosis of other neurodegenerative diseases such as Parkinson's disease or ALS.
7T MRI contraindications:
- Large tattoos close to the head region, permanent makeup or unremoveable piercings
- Certain models of pacemakers (if pacemaker implantet, MRI physicist at 7T-lab will be conferred)
- Implantet metal in body (clips, stents, prothesis, skrews, plates, teeth etc.)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Norway · 1 center
- Norwegian University of Sciene and Technology / Norges teknisk-naturvitenskapelige univers — Trondheim
Identifiers
NCT: NCT07118137 · 490656