Clinical Study on the Safety and Efficacy of Human Amniotic Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Climen 21 Tablets, hA-MSCs.
- Who it may be relevant to
- Registry conditions: Premature Ovarian Insufficiency. Basic parameters: 20 years — 40 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
A Randomized, Open-label, Parallel-controlled Clinical Study of Amniotic Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency
Overview
There is a high incidence of women suffering from Primary Ovarian Insufficiency (POI). So far, there was no treatment sufficient enough to cure POI. Cell therapy is a rapidly developing field and have shown immense promise in the treatment of ovarian dysfunction. In this study, the investigator will evaluate the safety of human Amniotic mesenchymal stem cells (hA-MSCs) therapy in women suffering from POI.
Detailed description
This clinical trial is designed to understand the safety and effectiveness of human amniotic membrane mesenchymal stem cells (hA-MSCs) in the treatment of primary ovarian insufficiency (POI). Human amniotic MSCs were infused back into the patients by intravenous injection. The trial was designed with two groups, 1) the control group by conventional hormone replacement therapy with oral Climen and 2) the stem cell treatment group by intravenous infusion of human amniotic membrane mesenchymal stem cells (hA-MSCs) combined with oral Climen hormone therapy. Patients were followed up every 2 weeks after the post-injection stem cells to observe their outcomes. The investigators focused on safety indicators, but also monitored hormone levels and signs of follicular growth to initially assess the effectiveness of the stem cells.
Interventions
- Drug Climen 21 Tablets
Climen is commonly used clinically as a hormone replacement therapy and was administered to all patients in both the control and experimental groups in this project. - Biological hA-MSCs
The patients who were part of the experimental group were administered oral Clomid medication in conjunction with a combined intravenous injection of human amniotic MSCs.
Primary outcome measures
- Temperature [Time frame: Up to 24 weeks]
- Pulse [Time frame: up to 24 weeks]
- Breaths per minute [Time frame: up to 24 weeks]
- Blood pressure [Time frame: 0-24 weeks]
Secondary outcome measures (5)
- Follicle-stimulating hormone (FSH) serum level [Time frame: Up to 24 weeks]
- Estradiol (E2) serum level [Time frame: Up to 24 weeks]
- Anti-Mullerian hormone (AMH) serum level [Time frame: up to 24 weeks]
- Number of antral follicle [Time frame: up to 24 weeks]
- Achievement of pregnancy [Time frame: up to 12 months]
Eligibility criteria
Inclusion criteria
- The intention of pregnant women aged >= 20 and < 40, with normal karyotype;
- Oligo/amenorrhea for at least 4 months;
- Elevated FSH level >25 IU/l on two occasions >4 weeks apart;
- Without a history of stem cell therapy and no growth hormone and/or estrogen and progesterone therapy within the previous 3 months;
- Voluntary participation in the study with signed informed consent;
Exclusion criteria
- Unable to follow the treatment observation process required by the trial;
- Genetic diseases, chromosomal abnormalities, and genetic deficiency that clearly cause premature ovarian insufficiency/premature ovarian failure;
- With breast, uterine, ovarian tumors, or any other benign or malignant tumors;
- Allergic history to drugs or any other things;
- Presence of genetic disorders such as Turner's syndrome, congenital malformations of the reproductive organs.
- Have undergone ovariectomy or have organic gynaecological diseases.
- Presence of other gynaecological endocrine diseases such as polycystic ovary syndrome.
- Severe functional impairment of vital organs.
- High risk factors for venous thromboembolism and abnormalities in coagulation mechanisms.
- Attending doctor considers inappropriate to take part in.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
China · 1 center
- Shanghai Changhai Hospital — Shanghai
Identifiers
NCT: NCT07115082 · CHEC2023-172