Central Venous Oxygen Saturation Prognostic Impact in Post Arrest Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Post Arrest Patients. Basic parameters: from 16 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Central Venous Oxygen Saturation Impact on Prognosis of Post Arrest Patients
Overview
The study aim will be to assess the prognostic impact and value of central venous oxygen saturation on post arrest patients.
Detailed description
Central venous oxygen saturation (ScvO₂) is a very important measurement which can be easily taken in a critical care environment by both medical and nursing staff. It provides an understanding of the patient's oxygen delivery, oxygen consumption and cardiac output. It has a key role within early goal-directed therapy and has been shown to decrease mortality when taken and analysed appropriately. (Central venous oxygen saturation: analysis, clinical use and effects on mortality,2013) Venous oxygen saturation (SvO2) measures the blood's oxygen content returning to the right side of the heart after perfusing the entire body. When the oxygen supply is insufficient to meet the metabolic demands of the tissues, an abnormal SvO2 ensues and reflects an inadequacy in systemic oxygenation. SvO2 is, therefore, dependent on oxygen delivery and oxygen extraction. Venous oximetry is used in specific clinical settings of hemodynamic instability, such as in critical illnesses, perioperative periods of major surgeries, heart failure, sepsis andd post arrest patients. The venous blood in the pulmonary artery represents oxygen extraction in the whole body and is called mixed venous oxygen saturation (SmvO2). It was measured using a pulmonary artery catheter (PAC). A second, less invasive method of measuring SvO2 is via a central venous catheter (CVC) positioned in the superior vena cava and is called the central venous oxygen saturation (ScvO2).
Central venous oxygen saturation (ScvO(2)) is suggested to reflect the adequacy of oxygen delivery, and the main objective of the present study was to determine whether ScvO(2) is associated with outcome in haemodynamically stabilized post arrest patients predicting mortality and outcome based on central venous oxygen saturation
Primary outcome measures
- central venous oxygen saturation impact on prognosis of post arrest patients [Time frame: time of follow up expected from time of successful ROSC until full improvement or recurrent arrest and death From date of cardiac arrest until date of first documented improvement or date of death due to any cause whichever came first assessed up in 2 mo]
Eligibility criteria
Inclusion criteria
- adults above 16 years old, critically ill patients
- both genders
- post arrest patients
Exclusion criteria
- if patients does not experience cardiac arrest
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Assiut university — Asyut
Publications
- Gallet R, Lellouche N, Mitchell-Heggs L, Bouhemad B, Bensaid A, Dubois-Rande JL, Gueret P, Lim P. Prognosis value of central venous oxygen saturation in acute decompensated heart failure. Arch Cardiovasc Dis. 2012 Jan;105(1):5-12. doi: 10.1016/j.acvd.2011.10.005. Epub 2012 Jan 13. PMID 22369912
- Grand J, Hassager C, Schmidt H, Molstrom S, Nyholm B, Hoigaard HF, Dahl JS, Meyer M, Beske RP, Obling L, Kjaergaard J, Moller JE. Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest. Crit Care. 2023 Oct 27;27(1):410. doi: 10.1186/s13054-023-04704-2. PMID 37891623
- Rodriguez-Scarpetta MA, Sepulveda-Tobon AM, Daza-Arana JE, Lozada-Ramos H, Alzate-Sanchez RA. Central Oxygen Venous Saturation and Mortality in Patients Undergoing Coronary Artery Bypass Grafting. Ther Clin Risk Manag. 2023 Jun 3;19:447-454. doi: 10.2147/TCRM.S407454. eCollection 2023. PMID 37292584
Identifiers
NCT: NCT07107776 · CVO2 prognosis in post arrest