Prosthetic Joint Infection : Lessons From Deceased Patients in Critical Care.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Global cohort.
- Who it may be relevant to
- Registry conditions: Osteoarticular Infections, Intensive Care Patients, Prosthetic Joint Infection. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Osteoarticular Sepsis In Intensive Care Units : a Retrospective Study About Deceased Patients.
Overview
This is an observational, retrospective, multicenter study based on the use of demographic, clinical and biological data from deceased patients admitted between 2018 and 2022 to critical care with a principal or associated diagnosis of joint prosthesis infection. Data from this study will be combined with that from the OASIS study (APHP241174/ ID-RCB: 2024-A01769-38) concerning osteoarticular sepsis on prosthetic material in critical care of living patients. The aim of this study is to improve our knowledge of the profile, care trajectories and outcomes of patients hospitalized in critical care in the context of osteoarticular material sepsis. The results of the study could help identify at-risk populations and improve management strategies for patients with osteoarticular sepsis.
Interventions
- Other Global cohort
All deceased patients admitted to intensive care during the study period and satisfying the eligibility criteria.
Primary outcome measures
- Epidemiological description of deceased patients [Time frame: 2 years]
Secondary outcome measures (3)
- Composite endpoint reflecting poor clinical outcome [Time frame: 2 years]
- Mortality at 2 years [Time frame: 2 years]
- Epidemiological description based on the number (n) and proportion (%) of bacterial strains found in samples collected during the operation. [Time frame: 2 years]
Eligibility criteria
Inclusion criteria
- Patient aged 18 years or older.
- Hospitalization in critical care (intensive care unit or continuing care unit) between 2018 and 2022, lasting at least 48 hours, with a prosthetic joint infection (hip, knee, or shoulder prosthesis infection) as the primary or associated diagnosis.
- Deceased patient who had not refused data processing.
Exclusion criteria
- Infection involving osteosynthesis material
- Infection involving spinal instrumentation
- Patient with multiple infected prostheses
- Recurrence of prosthetic infection with the same microorganism as a previous episode
- Patient under legal protection
- Pregnant or breastfeeding patient
- Patient deprived of liberty
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- Hôpital Lariboisière — Paris
Identifiers
NCT: NCT07107685 · APHP250872