A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Normal saline, Dexmedetomidine, Methylprednisolone.
- Who it may be relevant to
- Registry conditions: Coronary Artery Disease, Systemic Inflammatory Response Syndrome, Postoperative Complications. Basic parameters: 21 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
A comparison between precedex versus solumedrol as anti-inflammatory stress response inhibitors in patients undergoing on-pump CABG using different inflammatroy response parameters and the outcome of the drugs on the cognitive and cardiac status post extubation
Interventions
- Drug Normal saline
After induction of anesthesia give 10 ml of normal saline then followed by infusion of normal saline till extubation of patient in ICU - Drug Dexmedetomidine
After induction of anesthesia give loading dose of precedex 1 mcg/kg diluted in 10 ml normal saline then attach syringe pump of precedex infusion of 0.5mcg/kg/hr till extubation in ICU - Drug Methylprednisolone
After induction of anesthesia give solumedrol of a dose 10mg/kg diluted in 10ml of normal saline followed by a normal saline infusion till the extubation of the patient in the ICU
Primary outcome measures
- Induced inflammatory response [Time frame: First 24 hours post cardio-pulmonary bypass]
Secondary outcome measures (1)
- Cognitive function [Time frame: First 24 hours post cardio-pulmonary bypass]
Eligibility criteria
Inclusion criteria
- Age 21-60 years.
- Sex: Both sexes.
- American Society of Anaesthesiologists (ASA) Physical Status Class II, and III.
- Scheduled for CABG on cardio-pulmonary bypass.
Exclusion criteria
- Declining to give a written informed consent.
- History of allergy to the medications used in the study.
- Psychiatric disorders.
- Significant cognitive dysfunction.
- American Society of Anesthesiologists (ASA) Physical Status Class IV.
- Chronic liver or kidney disease.
- Poor systolic function ( Ejection fraction < 40% ).
- Pregnancy.
- Redo CABG.
9.Infection during the week preceding surgery white blood cell count over 11,000 mm3 10.Pre-operative use of antibiotics or corticosteroids.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Quadruple blind
- Primary purpose
- Supportive care
Study locations
Egypt · 1 center
- Ain Shams University — Cairo
Identifiers
NCT: NCT07101367 · FMASU MD219/2023