Bacteria in Dental Plaque and Atheroma Plaque
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: atheroma plaque, dental plaque.
- Who it may be relevant to
- Registry conditions: Gingival Inflammation, Dental Plaque, Atheroma Plaque, Oral Bacteria. Basic parameters: 18 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.
Detailed description
Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.
Severe chronic generalized periodontitis may result in systemic inflammation and endothelial dysfunction. Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS causes an early systemic inflammatory response in the intima.
The aim of this study is to assess the relationship between bacteria in atheroma plaque, and dental plaque in patients grouped using the new periodontal classification. In addition, the relationship between demographic findings and bacterial count and frequency will be evaluated.
Interventions
- Other atheroma plaque
During the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients. - Other dental plaque
Subgingival plaque samples will be collected from patients before the endarterectomy procedure.
Primary outcome measures
- Number of bacteria [Time frame: through study completion, an average of 2 months]
- Number of bacteria [Time frame: through study completion, an average of 2 months]
Eligibility criteria
Inclusion criteria
- Diagnosed with endarterectomy
- Not receiving chemotherapy
- Not having received this treatment before
Exclusion criteria
- Having systemic infection
- Patients with severe heart disease
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Other
Study locations
Turkey (Türkiye) · 1 center
- Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology — Istanbul
Identifiers
NCT: NCT07100574 · 1417