Hydrogen-Rich Water and Resting Metabolism in Young Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Molecular Hydrogen, Placebo Comparator.
- Who it may be relevant to
- Registry conditions: Healthy Subjects or Volunteers. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Effects of Hydrogen-Rich Water on Resting Metabolism in Healthy Young Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial
Overview
The H2REST trial is a randomized, double-blind, placebo-controlled crossover study investigating the acute effects of a single dose of hydrogen-rich water (HRW) on resting metabolism in healthy young adults. Participants complete two testing sessions-receiving either HRW or placebo in a randomized order-followed by standardized metabolic testing. Primary outcomes include resting energy expenditure, respiratory exchange ratio, and substrate utilization measured via indirect calorimetry. The study aims to assess whether acute HRW intake can modulate metabolic rate and fuel preference at rest, and to explore inter-individual variability in response.
Interventions
- Dietary supplement Molecular Hydrogen
Participants in this arm will consume a single 250 mL dose of hydrogen-rich water containing approximately 1.6-2.0 ppm of dissolved molecular hydrogen (H₂), The HRW will be ingested following an overnight fast, and resting metabolism will be measured approximately 30-60 minutes post-consumption using indirect calorimetry. - Dietary supplement Placebo Comparator
Non-hydrogen-producing tablets, identical in appearance and taste to the active supplement
Primary outcome measures
- Resting Energy Expenditure (REE) [Time frame: Participants will attend three study visits, with each intervention separated by a 7-day washout period to minimize carry-over effects. During each visit, measurements will be conducted approximately 30-60 minutes post-intervention.]
Eligibility criteria
Inclusion criteria
- Aged 18-35 years
- BMI between 18.5 and 25.0 kg/m²
- Apparently healthy, with no history of chronic disease
- Non-smoker, not currently using nicotine-containing products
- Able to provide informed consent
- Willing to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each study visit
- Able to comply with study procedures, including fasting and attending all study visits
Exclusion criteria
- Diagnosed metabolic, cardiovascular, respiratory, gastrointestinal, or endocrine disorders
- Use of dietary supplements or medications affecting metabolism (within the past 2 weeks)
- Allergy or intolerance to components of the hydrogen or placebo beverages
- Pregnant or lactating
- Shift work or irregular sleep schedule
- Participation in another clinical study within the past 30 days
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Triple blind
- Primary purpose
- Basic science
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07098221 · 50-10-18/2024-3