Recruiting NCT07097480

Virus Transmission to People Recently Bitten or With a History of Monkey Bites "SIMVIR

No phase Interventional Bites Monkey

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied: The protocol lists: Blood samples collection, Saliva samples collection.
Who it may be relevant to: Registry conditions: Bites Monkey. Basic parameters: from 18 years · All.
What needs checking: Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place: France
Next step: Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Virus Transmission to People Recently Bitten or With a History of Monkey Bites "SIMVIR"

Overview

Nonhuman primates (NHPs) constitute an important reservoir of infectious agents, some of which have emerged in human populations as deadly pathogens. Human exposure to the biological fluids of NHPs - particularly through bites - can result in the transmission of several viruses. Only the rabies virus is currently targeted by post-exposure prophylaxis following an injury caused by an NHP. The objective of the study is to investigate the prevalence of STLV-1 and SFV infections following a nonhuman primate bite.

Detailed description

Compared to other individuals exposed to nonhuman primates (NHPs), travelers have two unique characteristics. First, they are typically exposed only once to simian infectious agents, in contrast to the repeated exposure experienced by other at-risk groups. If exposure results in an infection event, travelers may spread these infectious agents to geographic areas where they do not normally circulate.

To address the following main objective: to study the prevalence of STLV-1 and SFV infections following a nonhuman primate bite. The study plans to include subjects who have been recently bitten as well as those with a history of nonhuman primate bites. Blood and saliva samples will be collected from the subjects.

Interventions

Procedure Blood samples collection
Blood samples of 40 ml will be taken.
Procedure Saliva samples collection
Saliva samples will be collected

Primary outcome measures

Study the prevalence of STLV-1 and SFV infections following an NHP bite. [Time frame: 17 months]

Secondary outcome measures (1)

Identify risk and demographic factors associated with STLV-1 and SFV infection. [Time frame: 17 months]

Eligibility criteria

Inclusion criteria

Age ≥ 18 years
Bite inflicted by an HNP (WHO category 3 level)
Written informed consent
Affiliation with a social security scheme (excluding State Medical Aid

Specific criteria for genetic analyses:

Participant has checked the boxes for participation in the genetic component.

Exclusion criteria

Patient presenting only with scratches inflicted by a PNH
Medical management incompatible with the objectives of the study
Patient who, in the doctor's opinion, is unlikely to comply with the study protocol
Health conditions are incompatible with the sample collection required by the study
Patient under legal protection (guardianship or trusteeship)

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation: Non-randomized
Model: Parallel assignment
Masking: Open label
Primary purpose: Other

Study locations

France · 1 center

Institut Pasteur Medical Center — Paris

Identifiers

NCT: NCT07097480 · 2024-113

Primary sources (government registries)

ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗