The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: PvCO2-PaCO2/CaO2-CvO2 ratio.
- Who it may be relevant to
- Registry conditions: Septic Shock. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Morocco
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Prognostic Value and Kinetics of the PvCO2-PaCO2/CaO2-CvO2 Ratio Compared to Arterial Lactate in the Initial Phase of Septic Shock
Overview
The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to assess the prognostic value of the PvCO2-PaCO2/CaO2-CvO2 in the early phase of septic shock.
Detailed description
The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to compare the kinetics of the PvCO2-PaCO2/CaO2-CvO2 ratio with a classic marker of anaerobic metabolism (arterial lactate) in the early phase of septic shock.
Interventions
- Diagnostic test PvCO2-PaCO2/CaO2-CvO2 ratio
Patients diagnosed with septic shock will undergo serial measurements of arterial and venous blood gas analyses, arterial lactate levels, and calculation of the Pv-aCO₂/Ca-vO₂ ratio at predefined time points: H0 (baseline), H2, H6, H12, and H24. Calculation Formulas: 1. Arterial Oxygen Content (CaO₂):CaO2 = SaO2 × Hb × 1,34 + PaO2 × 0,0031 2. Venous Oxygen Content (CvO₂):CvO2 = SvO2 × Hb × 1,34 + PvO2 × 0,0031 3. Pv-aCO₂/Ca-vO₂ Ratio: P(v-a) CO2/C(a-v)O2=(PcvCO2-PaCO2)/(CaO2 -CcvO2).
Primary outcome measures
- Prognostic value of PvCO2-PaCO2/Ca O2-CvO2 in patients with septic shock [Time frame: From patient inclusion (baseilie = H0) then at H2, H6, H 12 and H24 (H = hours)]
Eligibility criteria
Inclusion criteria
Patients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia > 2 mmol/L despite adequate fluid resuscitation. Sepsis is defined by the presence of a suspected or confirmed infectious source associated with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological). \[Sepsis 3 criteria\]
Exclusion criteria
- Absence of central venous access.
- Central venous access not positioned in the superior vena cava (e.g., femoral access).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Morocco · 3 centers
- Avicenna Military Hospital — Marrakesh
- Avicenna Military Hospital — Marrakesh
- Department of critical care Medicine. Avicenna Military Hospital — Marrakesh
Publications
- Ospina-Tascon GA, Madrinan HJ. Combination of O2 and CO2-derived variables to detect tissue hypoxia in the critically ill patient. J Thorac Dis. 2019 Jul;11(Suppl 11):S1544-S1550. doi: 10.21037/jtd.2019.03.52. PMID 31388459
Identifiers
NCT: NCT07096284 · SEPSIS_CO2/O2_vs_lactate