Effects of Inspiratory Muscle Exercise on Health
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Eupnea, Intermittent inspiratory muscle training (IIMT).
- Who it may be relevant to
- Registry conditions: Intermittent Inspiratory Muscle Training, Eupnea. Basic parameters: 20 years — 45 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Acute Effects of Intermittent Inspiratory Muscle Training on Blood Glucose and Vascular Function Responses
Overview
The purpose of this study is to investigate whether inspiratory muscle training has an immediate effect on energy expenditure, heart rate, blood glucose, blood pressure, and arterial stiffness in healthy adults, obese adults, and adults with type 2 diabetes.
Detailed description
Participants will be asked to complete two trials involving intermittent exercise, which will include eupnea and inspiratory muscle training (IMT), as well as a resting control condition, in a randomized crossover study design. The trials will be separated by a minimum of 48 hours and will be completed within a 7-day period. Throughout all trials, participants will be required to remain relaxed and seated on an adjustable examination bed. For the IMT intensity, participants will utilize an inspiratory muscle training device (PowerBreathe Plus, Powerbreathe International Ltd., UK) and adjust the resistance to a level at which breathing continuously for 20 breaths is perceived as "somewhat hard" (RPE = 13), according to the Rating of Perceived Exertion (RPE) scale. This will take place during a 3.5-hour oral glucose tolerance test (OGTT). During the trials, participants may watch television or read; however, typing on a laptop or computer will be prohibited.
Interventions
- Behavioral Eupnea
Participants will breathe normally. - Behavioral Intermittent inspiratory muscle training (IIMT)
Intermittent inspiratory muscle training (IIMT) will be conducted throughout the trial
Primary outcome measures
- Blood glycaemic responses [Time frame: 0 (baseline), 30, 60, 120, and 210 minutes during the 210-minute trial]
- Pulse wave velocity (PWV) [Time frame: 0 (baseline), 30, 60, 90, 150, and 210 minutes during the 210-minute trial]
Secondary outcome measures (4)
- Energy expenditure [Time frame: First 90 minutes during the 210-minute trial]
- Heart Rate Variability (HRV) [Time frame: In a regular patterns during the 210-minute trial]
- Visual analogue scale (VAS) [Time frame: Every 30 minutes during the 210-minute trial]
- Perceived stress scale (PSS) [Time frame: Every 30 minutes during the 210-minute trial]
Eligibility criteria
Inclusion criteria
- Healthy adults, obese adults and adults with type 2 diabetes
- Aged between 20 to 45 years
- Weight stable for more than 3 months (no change in weight +/- 3%)
- Non-smoker
- Non-highly trained athletic team members
- Normal lifestyle patterns
Exclusion criteria
- Personal history of/existing hypertension, respiratory infectious disease, cardiovascular disease, metabolic disease
- Taking medications that may influence lipid or carbohydrate metabolism or immune system function
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07095179 · 202506HM022