Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: fMRI, Questionnaires and surveys, Behavioral tasks and eye tracking.
- Who it may be relevant to
- Registry conditions: Substance Use, Healthy. Basic parameters: 18 years — 22 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: \- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.
Interventions
- Device fMRI
Participants will have an MRI to scan participants brains and will wear skin conductance electrodes on the hand and fill out questionnaires. Scanning will take approximately 90 minutes. While lying in the scanner, participants will be asked to perform some tasks. The tasks will be presented to participants visually on a screen in the scanner and eye movements will also be tracked during some of these tasks. Participants will respond to stimuli with button presses that are recorded by computer. - Behavioral Questionnaires and surveys
Participants will have multiple visits during this study and fill out various surveys at these visits. - Behavioral Behavioral tasks and eye tracking
Participants will perform behavioral tasks while having eye-tracking hardware monitor participants eye movements. A video camera will be used to record eye movements during the behavioral tasks.
Primary outcome measures
- Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score [Time frame: Baseline]
Secondary outcome measures (1)
- Correlation between PavCA bias score (out-of-scanner) and activation from the Cannabis Cue Reactivity Task (P-CAN) [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- 18-22 years old at baseline
- Right-handed
- Medically/physically able to give informed consent
- English-speaking
- Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)
Exclusion criteria
- Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
- History of psychosis in self or first-degree relative
- Current treatment for substance use disorder
- Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
- Intelligence quotient (IQ) < 70
- Lifetime history of head trauma with loss of consciousness > 5 minutes
- Reliance on glasses to be able to read small text at a distance of approximately 30 inches
- Colorblindness
- MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 2 centers
- Rachel Upjohn Building — Ann Arbor
- University of Michigan — Ann Arbor
Identifiers
NCT: NCT07094061 · HUM00269332 · R01DA058010