Evaluation of C-arm PCD-CBCT for Image-Guided Interventions
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: C-arm PCD-CBCT.
- Who it may be relevant to
- Registry conditions: Imaging. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Evaluation of C-arm Photon Counting Detector Cone Beam CT (PCD-CBCT) for Image-Guided Interventions
Overview
The overarching objective of the project is to develop a new C-arm interventional x-ray imaging platform that integrates both a photon counting detector and a flat panel detector to provide high image quality and quantitative spectral computed tomography (CT) image guidance will be developed to enable more accurate and safe interventional procedures for patients.
Detailed description
The objective of this pilot study is to assess the feasibility of acquiring high-quality images using new imaging concepts and methods. All imaging will be performed in addition to standard-of-care procedures and will not influence clinical decisions or patient management.
The endpoint of this project includes: 1) PCD-CBCT data will be processed to generate virtual non-iodine images for evaluating contrast extravasation, as well as virtual monoenergetic (VME) images. 2) Images will be analyzed retrospectively to evaluate image quality and explore potential clinical benefits of PCD-CBCT compared to flat panel detector cone beam CT (FPD-CBCT) and multidetector computed tomography (MDCT).
Interventions
- Device C-arm PCD-CBCT
A single research PCD-CBCT scan will be performed directly after the participant's SOC scan.
Primary outcome measures
- Mean Confidence Score for Calcifications [Time frame: after participant data collection is complete (up to 1 year)]
- Mean Confidence Score for Metal Artifacts [Time frame: after participant data collection is complete (up to 1 year)]
- Area Under the Curve (AUC) for Calcification Detection [Time frame: image analysis will proceed after participant data collection is complete (up to 2 years)]
Eligibility criteria
Inclusion criteria
- Not pregnant or breastfeeding
- Scheduled to receive image-guided intervention (IGI) of the head or the body
- Pre-treatment multidetector computed tomography (MDCT) images available
Exclusion criteria
- Unable to provide informed consent on their own behalf due to cognitive impairment
- Pregnant or breastfeeding
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- UW Hospital and Clinics — Madison
Identifiers
NCT: NCT07092553 · 2025-0677 · 1R01EB034011-01A1 · A534800 · SMPH/MED PHYSICS/MED PHYSIC · Protocol Version 3/10/2025