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Not yet recruiting NCT07084194

Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence

No phase Interventional Postoperative Pain Flare up Flare Up, Symptom

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Chitosan Nanoparticles Irrigant, aloe vera nanoparticles irrigant, Diode Laser Activation, ultrasonic activator.
Who it may be relevant to
Registry conditions: Postoperative Pain, Flare up, Flare Up, Symptom. Basic parameters: No limits · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence: A Randomized Clinical Study

Overview

This study aimed to evaluate and compare impact of integrating passive ultrasonic activation and laser activation with nano-chitosan and aloe vera in terms of postoperative pain and flare-up incidence in a randomized clinical trial.

Interventions

  • Other Chitosan Nanoparticles Irrigant
    using Chitosan Nanoparticles irrigant as a final irrigation solution.
  • Other aloe vera nanoparticles irrigant
    using Aloe Vera Nanoparticles irrigant as a final irrigation solution.
  • Device Diode Laser Activation
    activation of nanoparticles irrigants using diode laser
  • Device ultrasonic activator
    activation of nanoparticles irrigants using ultrasonic activator

Primary outcome measures

  • postoperative pain intensity Postoperative pain is to be assessed using visual analog scale (VAS), A scale from (0 to 10) where "0" means no pain and "10 means a severe pain that has never faced before. [Time frame: [Time Frame: 6, 12, 24, 48, 72 hours and 7 days after the first visit to collect the postoperative pain data.]]
Secondary outcome measures (1)
  • Flare-Up Incidence Flare-up is assessed through asking the patient to notify the investigator if any sudden severe pain or swelling takes place. [Time frame: [Time Frame: Within 7 days post-treatment)]

Eligibility criteria

Inclusion criteria

  • Age 18-60 (adults only)
  • multiple-rooted with multiple root canal.
  • Permanent teeth with mature apex and complete root formation.
  • Without root caries.
  • Tooth must be restorable.
  • Without anatomical abnormalities such as fusion.
  • Healthy patient category I according to ASA.
  • Vital tooth, with acute irreversible pulpitis and without peri-apical periodontitis.
  • No periapical radiolucency.
  • Consent Patients for who consent to participate and attend follow-up appointments.

Exclusion criteria

  • single root canals or double root.
  • Root canal calcifications.
  • Root resorption or fracture.
  • Previously root canal treated teeth.
  • immunocompromised patients.
  • Pregnant females
  • Patients with systemic diseases as diabetic or hypertension patients.
  • Patients with facial swelling.
  • patients who use analgesics or antibiotics within 48-72 hours.
  • Allergy to any materials used (e.g., irrigants or anesthetics).
  • psychiatric illness
  • Teeth that are not indicated for endodontic treatment: bad oral hygiene, mobile teeth, or recessed teeth.
  • Previously endodontically treated teeth.
  • Teeth with sinus tract.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Other

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07084194 · EC Reaseach NO.1079

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗