Precision Stratification for Frailty and Cognitive Decline
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session.
- Who it may be relevant to
- Registry conditions: Frailty, Cognitive Decline. Basic parameters: 60 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Singapore
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Precision Care Pathway Through Frailty and Cognitive Assessment Among Older Adults and Development of Care4Senior App, Intensive Aerobic Resistance Training and Brain Health Program in the Community
Overview
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks trial period to prevent frailty and promote social bonding.
Detailed description
In the Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial, participants will use the Care4Seniors 2.0 mobile application, in which physical and cognitive exercises will be provided to participants using this digital technology. Weekly in-person group exercise and cognitive sessions will also be conducted to prevent frailty, promote social bonding, as well as reduce social isolation and loneliness.
In the long term, this new service model has the potential to transform care, contain healthcare cost inflation and increase the efficiency of the lean manpower. It will translate knowledge into practice, resulting in impactful outcomes such as better self-management and healthy longevity. The CIRTAB program will raise the awareness of health behaviour, thus attracting more older adults to engage in preventive health and thus better prepare them for healthy ageing.
Interventions
- Behavioral Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB)
Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) - Behavioral Centre-Based Exercise Health Session
Participants will receive one time centre-based exercise health programme each week.
Primary outcome measures
- Frailty Status: - Edmonton Frailty Scale - Clinical Frailty Scale - Oral Frailty Index-8 [Time frame: From enrollment to the end of treatment at 12 weeks.]
- Presence of Sarcopenia: - Strength, Assistance with walking, Rise from a chair, Climb stairs, and Falls (SARC-F) Questionnaire [Time frame: From enrollment to the end of treatment at 12 weeks.]
- Presence of Cognitive Decline: - Montreal Cognitive Assessment - Symbol Digit Modalities Test - Cognitive Predictive Risk Score (developed from previous study) [Time frame: From enrollment to the end of treatment at 12 weeks.]
- Immunological Biomarkers: - C1q (complement component 1q) - IL-6 (Interleukin-6) [Time frame: From enrollment to the end of treatment at 12 weeks.]
- Skeletomuscular Biomarkers: - IGF-1 (Insulin-like Growth Factor-1) - Myostatin [Time frame: From enrollment to the end of treatment at 12 weeks.]
Secondary outcome measures (4)
- Self-Care Ability - Self-Care of Chronic Illness Inventory (SCCII) [Time frame: From enrollment to the end of treatment at 12 weeks.]
- Physical Activity Level - Global Physical Activity Questionnaire (GPAQ) [Time frame: From enrollment to the end of treatment at 12 weeks.]
- Physical Function - Short Physical Performance Battery (SPPB) [Time frame: From enrollment to the end of treatment at 12 weeks.]
- Intrinsic Capacity - World Health Organization (WHO) Integrated Care for Older People (ICOPE) tool [Time frame: From enrollment to the end of treatment at 12 weeks.]
Eligibility criteria
Inclusion criteria
- Older Adults Aged 60 to 85 years old
- Living in the community
- Formally diagnosed with at least one chronic disease
- Able to communicate in either English or Mandarin
Exclusion criteria
- Severe vision or hearing impairment
- Diagnosed with severe cognitive impairment (e.g. dementia)
- Diagnosed with severe psychiatric disorders (e.g. psychotic disorders, major depressive disorder)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
Singapore · 1 center
- Active Ageing Centres Under Changi General Hospital's Community Health Team Cluster (East — Singapore
Identifiers
NCT: NCT07081282 · NUS-IRB-2023-526