Serum Testosterone Level on Angiographic Complexity of Coronary Lesions in Premature Ischemic Egyptian Males
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Coronary Angiography, Syntax Score.
- Who it may be relevant to
- Registry conditions: Testosterone, Angiographic Complexity, Coronary Lesion, Premature Ischemia. Basic parameters: up to 45 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Impact of Serum Testosterone Level on Angiographic Complexity of Coronary Lesions in Premature Ischemic Egyptian Males
Overview
This study aims to investigate the association between serum testosterone levels and the angiographic complexity of coronary artery lesions in male patients under 45 years of age presenting with premature ischemic heart disease.
Detailed description
Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide. While traditionally associated with older populations, there is a growing incidence of premature CAD.
Testosterone, the primary male sex hormone, exerts various physiological effects beyond its role in reproductive function. It influences muscle mass, fat distribution, insulin sensitivity, and vascular tone. Low testosterone levels have been associated with adverse metabolic profiles, including increased adiposity, dyslipidemia, and insulin resistance, all of which are established risk factors for atherosclerosis. Furthermore, testosterone deficiency has been linked to endothelial dysfunction, a critical early event in the development of atherosclerotic plaques.
Interventions
- Other Coronary Angiography
All angiographic procedures will be performed. Coronary artery disease will be defined as \>70% stenosis in at least one major epicardial artery or \>50% the left main coronary artery. - Other Syntax Score
The angiographic complexity of coronary artery disease (CAD) will be assessed using the SYNTAX score.
Primary outcome measures
- Serum testosterone level [Time frame: Immediately after angiography (Up to 1 hour)]
Eligibility criteria
Inclusion criteria
- Male patients aged <45 years.
- Diagnosed with premature ischemic heart disease.
- Undergoing elective coronary angiography for suspected coronary artery disease (CAD) .
Exclusion criteria
- History of acute coronary syndrome within the preceding 3 months.
- Prior diagnosis of hypogonadism or history of testosterone replacement therapy or anabolic steroid use.
- Active neoplasm or history of chemotherapy.
- Known hepatic cirrhosis, chronic kidney disease, or end-stage renal disease.
- Use of medications known to affect sex hormone levels (e.g., spironolactone, ketoconazole).
- Endocrine disorders such as sickle cell anemia or celiac disease.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Sohag University — Sohag
Identifiers
NCT: NCT07076771 · Soh-Med-25-5-9PD