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Recruiting NCT07075926

Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit

— Observational Weaning Failure of Mechanical Ventilation

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Echocardiographic Assessment.
Who it may be relevant to
Registry conditions: Weaning Failure of Mechanical Ventilation. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit: A Prospective Observational Study

Overview

The goal of this prospective observational study is to evaluate whether left ventricular function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success from mechanical ventilation in adult intensive care unit (ICU) patients. The main questions it aims to answer are: Can the Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) predict successful extubation? What is the prognostic value of other echocardiographic measures such as Mitral Annular Plane Systolic Excursion (MAPSE), E/e' ratio, E/A ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index) in forecasting weaning outcomes? Participants will: Be adults receiving mechanical ventilation and scheduled for weaning Undergo transthoracic echocardiography (TTE) within 2 hours after meeting weaning criteria Have the following parameters measured: LVOT VTI, MAPSE, E/e', E/A, MDT, and Tei index Be monitored for 24 hours post-extubation to determine if they remain off ventilatory support, including reintubation, non-invasive ventilation, or high-flow oxygen therapy This study aims to provide a comprehensive understanding of how systolic, diastolic, and global cardiac functions influence extubation success, potentially improving ICU decision-making and reducing complications, length of stay, and healthcare costs.

Detailed description

This prospective, single-center observational study aims to assess the predictive value of left ventricular function parameters obtained via transthoracic echocardiography (TTE) in determining weaning success in mechanically ventilated adult ICU patients.

Following fulfillment of weaning criteria, patients will undergo TTE evaluation within 2 hours. The echocardiographic assessment will include the measurement of:

Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI)

Mitral Annular Plane Systolic Excursion (MAPSE)

E/e' ratio

E/A ratio

Mitral Deceleration Time (MDT)

Myocardial Performance Index (Tei index)

These measurements aim to reflect systolic, diastolic, and global left ventricular functions. After the echocardiographic assessment, patients will be followed for 24 hours to determine weaning success, defined as the ability to maintain spontaneous breathing without reintubation, non-invasive ventilation, or high-flow oxygen support.

By integrating non-invasive, bedside cardiac function assessments into the extubation decision-making process, the study seeks to contribute to more physiologically guided weaning strategies. The results may help reduce weaning-related complications and optimize resource use in critical care settings

Interventions

  • Diagnostic test Echocardiographic Assessment
    All participants will receive a standardized transthoracic echocardiographic (TTE) examination within 2 hours after meeting weaning criteria. The following cardiac function parameters will be recorded: LVOT Velocity Time Integral (VTI) Mitral Annular Plane Systolic Excursion (MAPSE) E/e' ratio E/A ratio Mitral Deceleration Time (MDT) Myocardial Performance Index (Tei index) The echocardiographic data will be used to investigate the association between left ventricular function and weaning

Primary outcome measures

  • Predictive Value of LVOT VTI in Determining Weaning Success [Time frame: Within 24 hours after extubation]
Secondary outcome measures (1)
  • Predictive Value of Additional Left Ventricular Function Parameters in Weaning Success [Time frame: Within 24 hours after extubation]

Eligibility criteria

Inclusion criteria

  • Currently receiving mechanical ventilation in the ICU
  • Planned extubation after meeting standard weaning criteria
  • Hemodynamically stable at the time of echocardiographic evaluation
  • Written informed consent obtained from the patient or legally authorized representative

Exclusion criteria

  • Surgery within the previous 24 hours
  • Presence of significant valvular heart disease or known cardiomyopathy
  • Inadequate acoustic window for transthoracic echocardiography
  • Ongoing use of extracorporeal support (e.g., ECMO)
  • Patients with Do-Not-Resuscitate (DNR) orders or expected to die within 24 hours
  • Re-intubation planned prophylactically regardless of clinical status
  • Pregnant patients

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Turkey (Türkiye) · 1 center
  • Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital — Istanbul

Identifiers

NCT: NCT07075926 · Weaning-Left Heart

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗