Neutrophil to Lymphocyte Ratio and Postdural Headache
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: PDPH.
- Who it may be relevant to
- Registry conditions: Preoperative Neutrophil-to-Lymphocyte Ratio (NLR), Postdural Puncture Headache. Basic parameters: from 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Preoperative Neutrophil-to-Lymphocyte Ratio as a Predictor of Post-Dural Puncture Headache Following Cesarean Section Under Spinal Anesthesia
Overview
This study will aim to investigate whether systemic inflammatory markers-especially the neutrophil-to-lymphocyte ratio (NLR)-obtained from preoperative complete blood counts can predict the development of post-dural puncture headache (PDPH) in obstetric patients undergoing cesarean section under spinal anesthesia.
Interventions
- Other PDPH
Observational analysis of preoperative inflammatory markers (e.g., NLR, PLR, SIRI) in relation to PDPH development following spinal anesthesia.
Primary outcome measures
- Postdural Puncture Headache (PDPH) incidence [Time frame: Within 10 days postoperatively]
Eligibility criteria
Inclusion criteria
- Women aged 18 years or older
- Underwent elective or emergency cesarean section under spinal anesthesia
- Had complete preoperative complete blood count (CBC) data available
- No known hematological or inflammatory disease
- No intraoperative complications recorded
- Medical records accessible for postoperative follow-up regarding PDPH symptoms
Exclusion criteria
- Age under 18
- Absence of preoperative complete blood count data
- Presence of hematologic malignancy, active infection, autoimmune disease, or immunosuppressive therapy
- Platelet count <150,000/mm³ or INR >1.5
- Incomplete or missing medical records
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Turkey (Türkiye) · 1 center
- Istinye Üniversity — Istanbul
Publications
- Olawin AM, Das JM. Spinal Anesthesia. 2022 Jun 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK537299/ PMID 30725984
- Sahin R, Tanacan A, Serbetci H, Agaoglu Z, Haksever M, Kara O, Sahin D. The Association of Systemic Immune-Inflammation Index (SII), Systemic Immune-Response Index (SIRI), and Neutrophil-to-Lymphocyte Ratio (NLR) with Cesarean Scar Pregnancy (CSP). J Reprod Immunol. 2024 Aug;164:104275. doi: 10.1016/j.jri.2024.104275. Epub 2024 Jun 4. PMID 38850761
- Bai YY, Xi Y, Yin BB, Zhang JH, Chen F, Zhu B. Reference intervals of systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio during normal pregnancy in China. Eur Rev Med Pharmacol Sci. 2023 Feb;27(3):1033-1044. doi: 10.26355/eurrev_202302_31199. PMID 36808350
Identifiers
NCT: NCT07075874 · NLR-PDPH ERKAN