TAC, SOD and MDA Responses to Aerobic Exercise Versus Phoenix Seed in Obese Sedentary Females
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: aerobic exercise, phoenix seed, aerobic exercise+ phoenix seed.
- Who it may be relevant to
- Registry conditions: Aerobic Exercise Phoenix Seed, Antioxidant Potential. Basic parameters: 35 years — 55 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
the aim of this study is To assess the antioxidant potential by measuring TAC, SOD and MDA responses to aerobic exercise versus phoenix seed in 60 obese sedentary females with symptoms of systemic inflammation. • All subjects will follow the given instructions strictly during the study duration, regarding the assessment and the treatment procedure, all participants will be evaluated under the same environmental conditions
Detailed description
reactive oxygen species (ROS) are generated as metabolic by-products by biological systems during Processes like protein phosphorylation, activation of several transcriptional factors, apoptosis, immunity, and differentiation. When ROS production increases, they start showing harmful effects on important cellular structures like proteins, lipids, and nucleic acids. A large body of evidences shows that oxidative stress can be responsible, with different degrees of importance in the onset and/or progression of several diseases as cancer, diabetes, metabolic disorders, atherosclerosis, and cardiovascular diseases.
Date seed is a waste product that is high in polyphenolics (a mjor antioxidant compounds), phenolicacid (allergic, epicatechin, catechol,chlorogenic), carotenoids, total dietary fiber (such as pectin, β-glucan, and arabinoxylan), fat, protein, minerals, and various other nutrients and functional elements Phytosterols as β-sitosterol, campesterol, and Δ5-avenasterol are The major components of date seed oil sterols (contents varied between 4.70 and 8.45 mg/g) are important micronutrients and essential structural components of the cellular membrane.they serve crucial functions, such as modulating membrane permeability and fluidity, antioxidant activity , cholesterol-lowering effects and anti-inflammatory properties in addition to their putative contribution to reducing the risk of cardiovascular diseases and affording benefits to the immune system.
Physical activity improves antioxidant defences, lowers lipid peroxidation levels and involved in the protection from cardiovascular disorders, type II diabetes, metabolic syndrome and neurodegenerative diseases like Alzheimer's disease both in adult and in aged individuals. Thus emphasizing the importance of regular physical activity to decelerate the aging-associated impairment process.
Myokines,the bioactive peptides released by skeletal muscle following exercise as acrucial regulator of metabolic and protective pathways in peripheral tissues, particularly in combating oxidative stress and inflammation through activating intracellular signalling pathways within the liver that are involved in the liver's antioxidant defences.
this study aims to compare between aerobic exercise and phoenix seed in their antioxidant potential.
Interventions
- Other aerobic exercise
the exercise protocol was applied following these characteristics * frequency: 3-5 times /week along the whole study period * intensity: 70% of the maximal heart rate (220- age x 70/100) * duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The resear - Dietary supplement phoenix seed
consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day - Combination product aerobic exercise+ phoenix seed
a specialized programme of aerobic exercise.the exercise protocol follow these characteristics * frequency: 3-5 times /week along the whole study period * intensity: 70% of the maximal heart rate (220- age x 70/100) * duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers a
Primary outcome measures
- TAC or total antioxidant capacity (blood test) [Time frame: test applied before and after 2 months of the intervention protocol]
- SOD (superoxide dismutase) [Time frame: Pre- intervention and after 8 weeks of treatment]
- MDA (malondialdehyde) [Time frame: Pre- intervention and after 8 weeks of treatment]
Eligibility criteria
Inclusion Criteria: sedentary obese female aged 35-55 years old with BMI of 30-39.9 and some symptoms of systemic inflammation (˃75 score at the inflammatory questionnaire) and had none of the exclusion criteria could be included in this study.
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Exclusion Criteria: patients with orthopaedic or cardiac or any health condition that could interfere the ability to walk or exercise
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07073716 · R.T.REC/012/005432