Phase 2 Trial to Evaluate the Safety and Tolerability and Early Bactericidal Activity of RESP30TB in Tuberculosis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: RESP30TB, HRZE (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol combination).
- Who it may be relevant to
- Registry conditions: Pulmonary Tuberculoses. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- South Africa
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
A Phase 2 Trial to Evaluate the Safety and Tolerability and Early Bactericidal Activity of Nebulised RESP30TB in Adults With Newly Diagnosed, Rifampicin Susceptible Pulmonary Tuberculosis
Overview
A Phase 2 Trial to Evaluate the Safety and Tolerability and Early Bactericidal Activity of Nebulised RESP30TB in Adults with Newly Diagnosed, Rifampicin Susceptible Pulmonary Tuberculosis
Detailed description
This is a single-centre, open-label, single arm, clinical trial in two sequential stages, with no stratification. 12 patients will be enrolled in Stage 1, and a further 12 patients will be enrolled in Stage 2 (total of 24 patients in the trial).
Interventions
- Drug RESP30TB
Nitric Oxide agent - Drug HRZE (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol combination)
isoniazid 75 mg (H), rifampicin 150 mg (R), pyrazinamide 400 mg (Z), ethambutol 275 mg (E)
Primary outcome measures
- Safety and Tolerability of Inhaled RESP30TB Measured as Number of Treatment Emergent Adverse Events (TEAEs) [Time frame: Dosing period 14 days + Follow-up period 14 days]
Eligibility criteria
Inclusion criteria
- Provide written, informed consent prior to all trial-related procedures and agree to undergo all trial procedures.
- Body weight (in light clothing and with no shoes) between 40 and 90 kg, inclusive.
- Newly diagnosed pulmonary TB.
- Rifampicin susceptible pulmonary TB as determined by molecular testing.
- Ability to produce an adequate volume of sputum as estimated from a pre-treatment overnight sputum collection sample (estimated 10 mL or more).
- Spirometry performed during screening with a Forced Expiration Volume in the first second (FEV1) of ≥ 40%.
- Be of non-childbearing potential or willing to use effective methods of contraception, as defined in section 4.3.4.
Exclusion criteria
- HIV positive AND CD4 < 350 cells/mm3 OR are receiving antiviral therapy (ART)
- Baseline Methaemoglobin saturation (SpMet) >3%.
- Female patients who is pregnant or breast-feeding.
- Patients planning to conceive a child within the anticipated period of trial participation and for at least 90 days after the last dose of IMP in the trial.
- Participation in other clinical studies with investigational agents within 8 weeks prior to screening.
- Treatment received for this episode of TB with any drug active against M.tb
- Treatment with immunosuppressive medications such as TNF-alpha inhibitors within 2 weeks prior to screening, or systemic corticosteroids for more than 7 days within 2 weeks prior to screening.
- Treatment with NO and other NO donor agents, phosphodiesterase inhibitors and lung surfactant drugs, within 30 days prior to screening.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Sequential
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
South Africa · 1 center
- TASK Clinical Research Centre — Cape Town
Identifiers
NCT: NCT07073638 · RESP30TB-EBA